Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses
Following the 2009 H1N1 pandemic and ongoing sporadic avian-to-human transmission of H5N1 viruses, an emphasis has been placed on better understanding the determinants and pathogenesis of severe influenza infections. Much of the current literature has focused on viral genetics and its impact on host...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/797180 |
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| _version_ | 1832552240499392512 |
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| author | Jennifer Juno Keith R. Fowke Yoav Keynan |
| author_facet | Jennifer Juno Keith R. Fowke Yoav Keynan |
| author_sort | Jennifer Juno |
| collection | DOAJ |
| description | Following the 2009 H1N1 pandemic and ongoing sporadic avian-to-human transmission of H5N1 viruses, an emphasis has been placed on better understanding the determinants and pathogenesis of severe influenza infections. Much of the current literature has focused on viral genetics and its impact on host immunity as well as novel risk factors for severe infection (particularly within the H1N1 pandemic). An understanding of the host genetic determinants of susceptibility and severe respiratory illness, however, is currently lacking. By better defining the role of genetic variability in influenza infection and identifying key polymorphisms that impair the host immune response or correlate with protection, we will be able to better identify at-risk populations and new targets for therapeutic interventions and vaccines. This paper will summarize known immunogenetic factors associated with susceptibility or severity of both pH1N1 and H5N1 infections and will also identify genetic pathways and polymorphisms of high relevance for future study. |
| format | Article |
| id | doaj-art-975500eb95654c828e51ada3220cb7a9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-975500eb95654c828e51ada3220cb7a92025-02-03T05:59:09ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/797180797180Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza VirusesJennifer Juno0Keith R. Fowke1Yoav Keynan2Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, R3E 0J9, CanadaDepartment of Medical Microbiology, University of Manitoba, Winnipeg, MB, R3E 0J9, CanadaDepartment of Medical Microbiology, University of Manitoba, Winnipeg, MB, R3E 0J9, CanadaFollowing the 2009 H1N1 pandemic and ongoing sporadic avian-to-human transmission of H5N1 viruses, an emphasis has been placed on better understanding the determinants and pathogenesis of severe influenza infections. Much of the current literature has focused on viral genetics and its impact on host immunity as well as novel risk factors for severe infection (particularly within the H1N1 pandemic). An understanding of the host genetic determinants of susceptibility and severe respiratory illness, however, is currently lacking. By better defining the role of genetic variability in influenza infection and identifying key polymorphisms that impair the host immune response or correlate with protection, we will be able to better identify at-risk populations and new targets for therapeutic interventions and vaccines. This paper will summarize known immunogenetic factors associated with susceptibility or severity of both pH1N1 and H5N1 infections and will also identify genetic pathways and polymorphisms of high relevance for future study.http://dx.doi.org/10.1155/2012/797180 |
| spellingShingle | Jennifer Juno Keith R. Fowke Yoav Keynan Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses Clinical and Developmental Immunology |
| title | Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses |
| title_full | Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses |
| title_fullStr | Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses |
| title_full_unstemmed | Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses |
| title_short | Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses |
| title_sort | immunogenetic factors associated with severe respiratory illness caused by zoonotic h1n1 and h5n1 influenza viruses |
| url | http://dx.doi.org/10.1155/2012/797180 |
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