Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice
Exposure to PM2.5 is recognized to significantly impact the development of cardiovascular diseases, particularly hypertension, which has been recently attributed to an abnormal microenvironment characterized by disordered gut microbiota. Despite this recognition, the impacts of modulating gut microb...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325010413 |
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| author | Kaixin Yan Siyuan Wang Minjie Wang Yaxuan Yao Xiaoyan Liu Jiawei Song Yihang Chen Yufei Chen Ruiqiang Qi Xinyu Zhou Jiuchang Zhong Chaowei Hu Ying Dong Jing Li |
| author_facet | Kaixin Yan Siyuan Wang Minjie Wang Yaxuan Yao Xiaoyan Liu Jiawei Song Yihang Chen Yufei Chen Ruiqiang Qi Xinyu Zhou Jiuchang Zhong Chaowei Hu Ying Dong Jing Li |
| author_sort | Kaixin Yan |
| collection | DOAJ |
| description | Exposure to PM2.5 is recognized to significantly impact the development of cardiovascular diseases, particularly hypertension, which has been recently attributed to an abnormal microenvironment characterized by disordered gut microbiota. Despite this recognition, the impacts of modulating gut microbiota with short chain fatty acids (SCFAs) and high-fiber diets (HF) on mitigating PM2.5-induced hypertension remain unclear. Our study demonstrates that mice supplemented with SCFAs or a HF exhibit reduced blood pressure, improved vascular remodeling, and alleviated gastrointestinal tract damages compared to those exposed to PM2.5 alone. These dietary interventions altered the gut microbiota composition of PM2.5-exposed mice, including alpha-diversity, beta-diversity patterns, and enriched profiles of intestinal microbes such as Lactobacillus, Bacteroides, and Ruminococcaceae. Furthermore, SCFAs and HF modulated the fecal metabolome by increasing the abundance of metabolites like Bufalin, Glycocholic acid, Syringaresinol and Equol. These microbial and metabolic alterations are proposed to affect host metabolism by influencing steroidogenesis and arachidonic acid metabolism pathways, which in turn regulate blood pressure through enhanced vascular function and decreased vascular remodeling. In summary, modulation of gut microbiota by SCFAs or a HF plays a protective role against PM2.5-induced hypertensive damages, suggesting a potential strategy to reduce environmental pollution-related cardiovascular risks through gut microbiota modulation. |
| format | Article |
| id | doaj-art-97534896eb084c98a3fb9c438a7691f7 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-97534896eb084c98a3fb9c438a7691f72025-08-20T03:03:53ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211869610.1016/j.ecoenv.2025.118696Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in miceKaixin Yan0Siyuan Wang1Minjie Wang2Yaxuan Yao3Xiaoyan Liu4Jiawei Song5Yihang Chen6Yufei Chen7Ruiqiang Qi8Xinyu Zhou9Jiuchang Zhong10Chaowei Hu11Ying Dong12Jing Li13Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaMedical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaMedical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaMedical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaBeijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; Correspondce author.Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Correspondence to: Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Hypertension, 8th Gongtinanlu Rd, Chaoyang District, Beijing, China.Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Correspondence to: Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Hypertension, 8th Gongtinanlu Rd, Chaoyang District, Beijing, China.Exposure to PM2.5 is recognized to significantly impact the development of cardiovascular diseases, particularly hypertension, which has been recently attributed to an abnormal microenvironment characterized by disordered gut microbiota. Despite this recognition, the impacts of modulating gut microbiota with short chain fatty acids (SCFAs) and high-fiber diets (HF) on mitigating PM2.5-induced hypertension remain unclear. Our study demonstrates that mice supplemented with SCFAs or a HF exhibit reduced blood pressure, improved vascular remodeling, and alleviated gastrointestinal tract damages compared to those exposed to PM2.5 alone. These dietary interventions altered the gut microbiota composition of PM2.5-exposed mice, including alpha-diversity, beta-diversity patterns, and enriched profiles of intestinal microbes such as Lactobacillus, Bacteroides, and Ruminococcaceae. Furthermore, SCFAs and HF modulated the fecal metabolome by increasing the abundance of metabolites like Bufalin, Glycocholic acid, Syringaresinol and Equol. These microbial and metabolic alterations are proposed to affect host metabolism by influencing steroidogenesis and arachidonic acid metabolism pathways, which in turn regulate blood pressure through enhanced vascular function and decreased vascular remodeling. In summary, modulation of gut microbiota by SCFAs or a HF plays a protective role against PM2.5-induced hypertensive damages, suggesting a potential strategy to reduce environmental pollution-related cardiovascular risks through gut microbiota modulation.http://www.sciencedirect.com/science/article/pii/S0147651325010413PM2.5Gut microbiotaHigh fiber dietShort chain fatty acidsHypertension |
| spellingShingle | Kaixin Yan Siyuan Wang Minjie Wang Yaxuan Yao Xiaoyan Liu Jiawei Song Yihang Chen Yufei Chen Ruiqiang Qi Xinyu Zhou Jiuchang Zhong Chaowei Hu Ying Dong Jing Li Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice Ecotoxicology and Environmental Safety PM2.5 Gut microbiota High fiber diet Short chain fatty acids Hypertension |
| title | Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice |
| title_full | Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice |
| title_fullStr | Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice |
| title_full_unstemmed | Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice |
| title_short | Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM2.5-induced hypertension in mice |
| title_sort | modulating gut microbiota with scfas and high fiber diets to mitigate pm2 5 induced hypertension in mice |
| topic | PM2.5 Gut microbiota High fiber diet Short chain fatty acids Hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325010413 |
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