Platelet‐derived lipids promote insulin secretion of pancreatic β cells
Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of sy...
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| Format: | Article |
| Language: | English |
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Springer Nature
2023-07-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202216858 |
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| author | Till Karwen Katarzyna Kolczynska‐Matysiak Carina Gross Mona C Löffler Mike Friedrich Angel Loza‐Valdes Werner Schmitz Magdalena Wit Filip Dziaczkowski Andrei Belykh Jonathan Trujillo‐Viera Rabih El‐Merahbi Carsten Deppermann Sameena Nawaz Benoit Hastoy Agnieszka Demczuk Manuela Erk Mariusz R Wieckowski Patrik Rorsman Katrin G Heinze David Stegner Bernhard Nieswandt Grzegorz Sumara |
| author_facet | Till Karwen Katarzyna Kolczynska‐Matysiak Carina Gross Mona C Löffler Mike Friedrich Angel Loza‐Valdes Werner Schmitz Magdalena Wit Filip Dziaczkowski Andrei Belykh Jonathan Trujillo‐Viera Rabih El‐Merahbi Carsten Deppermann Sameena Nawaz Benoit Hastoy Agnieszka Demczuk Manuela Erk Mariusz R Wieckowski Patrik Rorsman Katrin G Heinze David Stegner Bernhard Nieswandt Grzegorz Sumara |
| author_sort | Till Karwen |
| collection | DOAJ |
| description | Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet‐derived lipid classes to promote insulin secretion and identified 20‐Hydroxyeicosatetraenoic acid (20‐HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet‐derived 20‐HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals. |
| format | Article |
| id | doaj-art-974cd37e10194d4682e8df439ae20f8d |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-974cd37e10194d4682e8df439ae20f8d2024-11-10T12:37:47ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842023-07-0115912310.15252/emmm.202216858Platelet‐derived lipids promote insulin secretion of pancreatic β cellsTill Karwen0Katarzyna Kolczynska‐Matysiak1Carina Gross2Mona C Löffler3Mike Friedrich4Angel Loza‐Valdes5Werner Schmitz6Magdalena Wit7Filip Dziaczkowski8Andrei Belykh9Jonathan Trujillo‐Viera10Rabih El‐Merahbi11Carsten Deppermann12Sameena Nawaz13Benoit Hastoy14Agnieszka Demczuk15Manuela Erk16Mariusz R Wieckowski17Patrik Rorsman18Katrin G Heinze19David Stegner20Bernhard Nieswandt21Grzegorz Sumara22Rudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgNencki Institute of Experimental Biology, Polish Academy of SciencesInstitute of Experimental Biomedicine I, University Hospital WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgNencki Institute of Experimental Biology, Polish Academy of SciencesTheodor Boveri Institute, Biocenter, University of WürzburgNencki Institute of Experimental Biology, Polish Academy of SciencesNencki Institute of Experimental Biology, Polish Academy of SciencesNencki Institute of Experimental Biology, Polish Academy of SciencesRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRadcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill HospitalRadcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill HospitalNencki Institute of Experimental Biology, Polish Academy of SciencesRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgNencki Institute of Experimental Biology, Polish Academy of SciencesRadcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill HospitalRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgRudolf Virchow Center for Integrative and Translational Bioimaging, Julius‐Maximilians University of WürzburgAbstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet‐derived lipid classes to promote insulin secretion and identified 20‐Hydroxyeicosatetraenoic acid (20‐HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet‐derived 20‐HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.https://doi.org/10.15252/emmm.20221685820‐HETEdiabetesinsulin secretionplateletβ cell |
| spellingShingle | Till Karwen Katarzyna Kolczynska‐Matysiak Carina Gross Mona C Löffler Mike Friedrich Angel Loza‐Valdes Werner Schmitz Magdalena Wit Filip Dziaczkowski Andrei Belykh Jonathan Trujillo‐Viera Rabih El‐Merahbi Carsten Deppermann Sameena Nawaz Benoit Hastoy Agnieszka Demczuk Manuela Erk Mariusz R Wieckowski Patrik Rorsman Katrin G Heinze David Stegner Bernhard Nieswandt Grzegorz Sumara Platelet‐derived lipids promote insulin secretion of pancreatic β cells EMBO Molecular Medicine 20‐HETE diabetes insulin secretion platelet β cell |
| title | Platelet‐derived lipids promote insulin secretion of pancreatic β cells |
| title_full | Platelet‐derived lipids promote insulin secretion of pancreatic β cells |
| title_fullStr | Platelet‐derived lipids promote insulin secretion of pancreatic β cells |
| title_full_unstemmed | Platelet‐derived lipids promote insulin secretion of pancreatic β cells |
| title_short | Platelet‐derived lipids promote insulin secretion of pancreatic β cells |
| title_sort | platelet derived lipids promote insulin secretion of pancreatic β cells |
| topic | 20‐HETE diabetes insulin secretion platelet β cell |
| url | https://doi.org/10.15252/emmm.202216858 |
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