Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers
Introduction: Immune thrombocytopenia (ITP) is the most common cause of acquired bleeding in childhood, but little is known about the clinical course and outcomes in infants with ITP. Methods: This is a retrospective study of all infants (1–12 months of age) and toddlers (13–47 months of age) diagno...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2025-01-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-184 |
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| _version_ | 1823861485594476544 |
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| author | Anselm Chi-wai Lee |
| author_facet | Anselm Chi-wai Lee |
| author_sort | Anselm Chi-wai Lee |
| collection | DOAJ |
| description | Introduction:
Immune thrombocytopenia (ITP) is the most common cause of acquired bleeding in childhood, but little is known about the clinical course and outcomes in infants with ITP.
Methods:
This is a retrospective study of all infants (1–12 months of age) and toddlers (13–47 months of age) diagnosed with ITP from a single centre during a 13-year period. The following data were compared between the two patients groups: demographics, severity of bleeding, platelet counts, duration of illness, development of chronic ITP, treatment and association with recent vaccination.
Results:
Twenty-two infants and 30 toddlers were diagnosed and followed up for ITP during the study period. Infants with ITP generally had minor or mild bleeding (19, 86.4%) and seldom required treatment (7, 31.8%), and their thrombocytopenia resolved at a mean of 1.90 months after diagnosis. Besides age, the sex ratio, severity of bleeding, platelet counts and proportion that required treatment were comparable between infants and toddlers. Fewer infants developed chronic ITP (1/22 vs. 9/30, P = 0.032), but more infants had a history of vaccination in the preceding 6 weeks prior to diagnosis of ITP (13/22 vs. 1/30, P < 0.001).
Conclusion:
ITP in infants is almost always a self-limiting and transient illness, and the majority of cases do not require treatment. |
| format | Article |
| id | doaj-art-974bedae20004f2d8ef2ee730714094e |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-974bedae20004f2d8ef2ee730714094e2025-02-09T13:06:12ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352025-01-01661202310.4103/singaporemedj.SMJ-2021-184Immune thrombocytopenia in infants: a retrospective study with comparison to toddlersAnselm Chi-wai LeeIntroduction: Immune thrombocytopenia (ITP) is the most common cause of acquired bleeding in childhood, but little is known about the clinical course and outcomes in infants with ITP. Methods: This is a retrospective study of all infants (1–12 months of age) and toddlers (13–47 months of age) diagnosed with ITP from a single centre during a 13-year period. The following data were compared between the two patients groups: demographics, severity of bleeding, platelet counts, duration of illness, development of chronic ITP, treatment and association with recent vaccination. Results: Twenty-two infants and 30 toddlers were diagnosed and followed up for ITP during the study period. Infants with ITP generally had minor or mild bleeding (19, 86.4%) and seldom required treatment (7, 31.8%), and their thrombocytopenia resolved at a mean of 1.90 months after diagnosis. Besides age, the sex ratio, severity of bleeding, platelet counts and proportion that required treatment were comparable between infants and toddlers. Fewer infants developed chronic ITP (1/22 vs. 9/30, P = 0.032), but more infants had a history of vaccination in the preceding 6 weeks prior to diagnosis of ITP (13/22 vs. 1/30, P < 0.001). Conclusion: ITP in infants is almost always a self-limiting and transient illness, and the majority of cases do not require treatment.https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-184childidiopathic thrombocytopenic purpuraimmune thrombocytopenic purpuraplatelet disordersthrombocytopenia |
| spellingShingle | Anselm Chi-wai Lee Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers Singapore Medical Journal child idiopathic thrombocytopenic purpura immune thrombocytopenic purpura platelet disorders thrombocytopenia |
| title | Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers |
| title_full | Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers |
| title_fullStr | Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers |
| title_full_unstemmed | Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers |
| title_short | Immune thrombocytopenia in infants: a retrospective study with comparison to toddlers |
| title_sort | immune thrombocytopenia in infants a retrospective study with comparison to toddlers |
| topic | child idiopathic thrombocytopenic purpura immune thrombocytopenic purpura platelet disorders thrombocytopenia |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-184 |
| work_keys_str_mv | AT anselmchiwailee immunethrombocytopeniaininfantsaretrospectivestudywithcomparisontotoddlers |