Aging, cancer, and autophagy: connections and therapeutic perspectives
Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy and the progression of age-related decline. As organisms age, cellular stress, genomic instability, and an accumulation of senescent cells create a pro-inflammatory environment cond...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1516789/full |
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| author | Begoña Zapatería Esperanza Arias Esperanza Arias |
| author_facet | Begoña Zapatería Esperanza Arias Esperanza Arias |
| author_sort | Begoña Zapatería |
| collection | DOAJ |
| description | Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy and the progression of age-related decline. As organisms age, cellular stress, genomic instability, and an accumulation of senescent cells create a pro-inflammatory environment conducive to cancer development. Autophagy, a cellular process responsible for degrading and recycling damaged components, plays a pivotal role in this relationship. While autophagy acts as a tumor-suppressive mechanism by preventing the accumulation of damaged organelles and proteins, cancer cells often exploit it to survive under conditions of metabolic stress and treatment resistance. The interplay between aging, cancer, and autophagy reveals key insights into tumorigenesis, cellular senescence, and proteostasis dysfunction. This review explores the molecular connections between these processes, emphasizing the potential for autophagy-targeted therapies as strategies that could be further explored in both aging and cancer treatment. Understanding the dual roles of autophagy in suppressing and promoting cancer offers promising avenues for therapeutic interventions aimed at improving outcomes for elderly cancer patients while addressing age-related deterioration. |
| format | Article |
| id | doaj-art-9740fcdc03d84abcbe8923fc7dead038 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-9740fcdc03d84abcbe8923fc7dead0382025-01-28T08:52:52ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-01-011110.3389/fmolb.2024.15167891516789Aging, cancer, and autophagy: connections and therapeutic perspectivesBegoña Zapatería0Esperanza Arias1Esperanza Arias2Department of Medicine (Marion Bessin Liver Research Center), Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine (Marion Bessin Liver Research Center), Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United StatesEinstein Aging Research Center, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, United StatesAging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy and the progression of age-related decline. As organisms age, cellular stress, genomic instability, and an accumulation of senescent cells create a pro-inflammatory environment conducive to cancer development. Autophagy, a cellular process responsible for degrading and recycling damaged components, plays a pivotal role in this relationship. While autophagy acts as a tumor-suppressive mechanism by preventing the accumulation of damaged organelles and proteins, cancer cells often exploit it to survive under conditions of metabolic stress and treatment resistance. The interplay between aging, cancer, and autophagy reveals key insights into tumorigenesis, cellular senescence, and proteostasis dysfunction. This review explores the molecular connections between these processes, emphasizing the potential for autophagy-targeted therapies as strategies that could be further explored in both aging and cancer treatment. Understanding the dual roles of autophagy in suppressing and promoting cancer offers promising avenues for therapeutic interventions aimed at improving outcomes for elderly cancer patients while addressing age-related deterioration.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1516789/fullagingcancerautopaghyproteostasistherapeutics |
| spellingShingle | Begoña Zapatería Esperanza Arias Esperanza Arias Aging, cancer, and autophagy: connections and therapeutic perspectives Frontiers in Molecular Biosciences aging cancer autopaghy proteostasis therapeutics |
| title | Aging, cancer, and autophagy: connections and therapeutic perspectives |
| title_full | Aging, cancer, and autophagy: connections and therapeutic perspectives |
| title_fullStr | Aging, cancer, and autophagy: connections and therapeutic perspectives |
| title_full_unstemmed | Aging, cancer, and autophagy: connections and therapeutic perspectives |
| title_short | Aging, cancer, and autophagy: connections and therapeutic perspectives |
| title_sort | aging cancer and autophagy connections and therapeutic perspectives |
| topic | aging cancer autopaghy proteostasis therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1516789/full |
| work_keys_str_mv | AT begonazapateria agingcancerandautophagyconnectionsandtherapeuticperspectives AT esperanzaarias agingcancerandautophagyconnectionsandtherapeuticperspectives AT esperanzaarias agingcancerandautophagyconnectionsandtherapeuticperspectives |