Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells

Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells

Abstract Positive-sense RNA viruses, including SARS-CoV-1 and -2, DENV, and CHIKV, replicate in curved membrane compartments within host cells. Non-structural proteins (nsPs) critically regulate these nanoscale membrane structures, yet their curvature-dependent assembly remains elusive due to the ch...

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Main Authors: Xinwen Miao, Michelle Cheok Yien Law, Jatin Kumar, Choon-Peng Chng, Yongpeng Zeng, Yaw Bia Tan, Jiawei Wu, Xiangfu Guo, Lizhen Huang, Yinyin Zhuang, Weibo Gao, Changjin Huang, Dahai Luo, Wenting Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59402-0
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