A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies
Abstract The outbreak of monkeypox virus (MPXV) was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and the zoonotic disease caused by viral infection was renamed as “Mpox” on November 28, 2022. Currently, there is no approved vaccine or sp...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Exploration |
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| Online Access: | https://doi.org/10.1002/EXP.20230112 |
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| author | Lin Jiang Ailan Xu Lin Guan Yong Tang Guangshuai Chai Junya Feng Yueqi Wu Maochen Li Chuxie Zhang Xiaojing Liu Xiaolong Xu Qingquan Liu Lihua Song Yigang Tong Renald Blundell Huahao Fan |
| author_facet | Lin Jiang Ailan Xu Lin Guan Yong Tang Guangshuai Chai Junya Feng Yueqi Wu Maochen Li Chuxie Zhang Xiaojing Liu Xiaolong Xu Qingquan Liu Lihua Song Yigang Tong Renald Blundell Huahao Fan |
| author_sort | Lin Jiang |
| collection | DOAJ |
| description | Abstract The outbreak of monkeypox virus (MPXV) was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and the zoonotic disease caused by viral infection was renamed as “Mpox” on November 28, 2022. Currently, there is no approved vaccine or specific antiviral treatment for Mpox, and a main preventive strategy against MPXV infection remains the smallpox vaccine. Although there was an emergency use authorization (EUA) of Brincidofovir and Tecovirimat for the clinical treatment of clade II Mpox, while Tecovirimat failed to reduce the duration of Mpox lesions among patients infected with clade I Mpox in the Democratic Republic of the Congo (DRC). Therefore, it is still an urgent need to develop an effective medication. This review aims to enhance the understanding of Mpox and contribute to its prevention and treatment strategies, it provides a systemic introduction of the biological and epidemiological characteristics of MPXV, the clinical feature and diagnosis of Mpox, as well as treatment and prevention strategies, which will improve the comprehension about MPXV and offer potential strategies for clinical treatment. |
| format | Article |
| id | doaj-art-973412cfd5da44b4a59b2b6b9968281c |
| institution | OA Journals |
| issn | 2766-8509 2766-2098 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj-art-973412cfd5da44b4a59b2b6b9968281c2025-08-20T02:18:28ZengWileyExploration2766-85092766-20982025-04-0152n/an/a10.1002/EXP.20230112A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategiesLin Jiang0Ailan Xu1Lin Guan2Yong Tang3Guangshuai Chai4Junya Feng5Yueqi Wu6Maochen Li7Chuxie Zhang8Xiaojing Liu9Xiaolong Xu10Qingquan Liu11Lihua Song12Yigang Tong13Renald Blundell14Huahao Fan15College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaDepartment of Respiratory and Critical Care MedicineQianfo Mountain Hospital of Shandong UniversityJinan Shandong ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaDepartment of Biomedical EngineeringThe Chinese University of Hong KongHong Kong ChinaInstitute of PhotomedicineShanghai Skin Disease HospitalShanghai ChinaBeijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing ChinaBeijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing ChinaDepartment of Physiology and Biochemistry, Faculty of Medicine and SurgeryUniversity of MaltaImsida MaltaSchool of Life SciencesTianjin UniversityTianjin ChinaAbstract The outbreak of monkeypox virus (MPXV) was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and the zoonotic disease caused by viral infection was renamed as “Mpox” on November 28, 2022. Currently, there is no approved vaccine or specific antiviral treatment for Mpox, and a main preventive strategy against MPXV infection remains the smallpox vaccine. Although there was an emergency use authorization (EUA) of Brincidofovir and Tecovirimat for the clinical treatment of clade II Mpox, while Tecovirimat failed to reduce the duration of Mpox lesions among patients infected with clade I Mpox in the Democratic Republic of the Congo (DRC). Therefore, it is still an urgent need to develop an effective medication. This review aims to enhance the understanding of Mpox and contribute to its prevention and treatment strategies, it provides a systemic introduction of the biological and epidemiological characteristics of MPXV, the clinical feature and diagnosis of Mpox, as well as treatment and prevention strategies, which will improve the comprehension about MPXV and offer potential strategies for clinical treatment.https://doi.org/10.1002/EXP.20230112monkeypoxMpoxMPXVOrthopoxvirusviral outbreak |
| spellingShingle | Lin Jiang Ailan Xu Lin Guan Yong Tang Guangshuai Chai Junya Feng Yueqi Wu Maochen Li Chuxie Zhang Xiaojing Liu Xiaolong Xu Qingquan Liu Lihua Song Yigang Tong Renald Blundell Huahao Fan A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies Exploration monkeypox Mpox MPXV Orthopoxvirus viral outbreak |
| title | A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies |
| title_full | A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies |
| title_fullStr | A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies |
| title_full_unstemmed | A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies |
| title_short | A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies |
| title_sort | review of mpox biological characteristics epidemiology clinical features diagnosis treatment and prevention strategies |
| topic | monkeypox Mpox MPXV Orthopoxvirus viral outbreak |
| url | https://doi.org/10.1002/EXP.20230112 |
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