Effect of Central Pattern Generators Depended Different Walking Strategies on Gait Ability of Patients after Stroke
Objective:To investigate the effects of central pattern generators (CPG) based different walking strategies on gait ability and the fMRI appearance of patients after stroke, make sure that the effective connection in which CPG based different walking strategies could promote neural network recovery,...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of Rehabilitation Medicine
2017-04-01
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| Series: | 康复学报 |
| Subjects: | |
| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.02040 |
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| Summary: | Objective:To investigate the effects of central pattern generators (CPG) based different walking strategies on gait ability and the fMRI appearance of patients after stroke, make sure that the effective connection in which CPG based different walking strategies could promote neural network recovery, and optimize the intervention strategies of gait reconstruction for stroke patients.Methods:Twenty stroke hemiplegic patients were randomized into the treatment group and the control group, ten patients for each group. The treatment group received rehabilitation robot for lower-limb training, and the control group received functional electrical stimulation (FES) for eight weeks. The training lasted for 10~20 minutes everyday, six times a week. The ten meters maximum walking speed (MWS) and functional ambulation category (FAC) classification were used to assess the curative effect of two groups at the time of beginning and eight weeks later. All patients received brain scanning with 1.5 tesla magnetic resonance imaging scanner while they were acupunctured on the ipsilateral ankle (not acupuncture point) at the time of beginning and eight weeks later.Results:The ten meters MWS and FAC classification scores of two groups were increased significantly after eight week's therapy (<italic>P</italic><0.05), and the increasing amplitude of the treatment group was higher than those of the control group (<italic>P</italic><0.05). The contralateral sensory and motor cortex (SMG) activation of the patients in the treatment group increased significantly compared to the control group (<italic>P</italic><0.05) after eight weeks.Conclusion:The rehabilitation robot for lower-limb training with movement patterns repeat can increase exercise sensory input, activate the CPG neural networks, and evoke fMRI responses in somatosensory cortex and cerebrum sensory cortex in patients with stroke. This indicated that fMRI is valuable in exploring the mechanisms of CPG neural network, and possessing positive effects on the improvement of walking ability and the reshaping of neural networks. |
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| ISSN: | 2096-0328 |