Neuroendocrine neoplasms as a lynch syndrome manifestation: a case report and comprehensive literature review

Neuroendocrine neoplasms as a lynch syndrome manifestation: a case report and comprehensive literature review

Lynch syndrome (LS) is an autosomal dominant inherited disorder caused by pathogenic variants in DNA mismatch repair (MMR) genes, most commonly MLH1 and MSH2. LS significantly increases the risk of various cancers, including colorectal, endometrial, gastric, and ovarian malignancies. Neuroendocrine...

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Bibliographic Details
Main Authors: Maria Paula Bernal Zárate, Daniel Felipe Mendivelso-Gonzalez, William Camilo Torres, Angelica Maria González Clavijo, Diego Felipe Ballen, Rafael Parra Medina, Julián C. Riaño-Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
lynch syndrome
neuroendocrine neoplasms (NENs)
mismatch repair-deficient (dMMR)
neuroendocrine tumor (NET)
hereditary cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1587889/full
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