The Expression Regulation and Cancer-Promoting Roles of RACGAP1
RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac...
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2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/3 |
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| author | Jiacheng Lin Yuhao Zhu Zhaoping Lin Jindong Yu Xiaobing Lin Weiyuan Lai Beibei Tong Liyan Xu Enmin Li Lin Long |
| author_facet | Jiacheng Lin Yuhao Zhu Zhaoping Lin Jindong Yu Xiaobing Lin Weiyuan Lai Beibei Tong Liyan Xu Enmin Li Lin Long |
| author_sort | Jiacheng Lin |
| collection | DOAJ |
| description | RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac and RhoA in multiple cancers to mediate downstream oncogene overexpression by assisting in the nuclear translocation of signaling molecules and to promote cytokinesis by regulating the cytoskeleton or serving as a component of the central spindle. Contradictorily, it was also reported that RACGAP1 in gastric cancer could inactivate Rac and RhoA. In addition, studies have revealed that RACGAP1 can be a biomarker for prognosis, and its role in reducing doxorubicin sensitivity poses difficulties for treatment, while the current drug targets mainly focus on its downstream molecule. This article mainly reviews the expression regulation of RACGAP1 and its cancer-promoting functions through oncogene expression mediation and Rho-GTPase activation. |
| format | Article |
| id | doaj-art-9725121417fd41d8831812e6fb1844b9 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-9725121417fd41d8831812e6fb1844b92025-01-24T13:24:49ZengMDPI AGBiomolecules2218-273X2024-12-01151310.3390/biom15010003The Expression Regulation and Cancer-Promoting Roles of RACGAP1Jiacheng Lin0Yuhao Zhu1Zhaoping Lin2Jindong Yu3Xiaobing Lin4Weiyuan Lai5Beibei Tong6Liyan Xu7Enmin Li8Lin Long9Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaThe Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaRACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac and RhoA in multiple cancers to mediate downstream oncogene overexpression by assisting in the nuclear translocation of signaling molecules and to promote cytokinesis by regulating the cytoskeleton or serving as a component of the central spindle. Contradictorily, it was also reported that RACGAP1 in gastric cancer could inactivate Rac and RhoA. In addition, studies have revealed that RACGAP1 can be a biomarker for prognosis, and its role in reducing doxorubicin sensitivity poses difficulties for treatment, while the current drug targets mainly focus on its downstream molecule. This article mainly reviews the expression regulation of RACGAP1 and its cancer-promoting functions through oncogene expression mediation and Rho-GTPase activation.https://www.mdpi.com/2218-273X/15/1/3RACGAP1Rho-GTPasesECT2STAT3 |
| spellingShingle | Jiacheng Lin Yuhao Zhu Zhaoping Lin Jindong Yu Xiaobing Lin Weiyuan Lai Beibei Tong Liyan Xu Enmin Li Lin Long The Expression Regulation and Cancer-Promoting Roles of RACGAP1 Biomolecules RACGAP1 Rho-GTPases ECT2 STAT3 |
| title | The Expression Regulation and Cancer-Promoting Roles of RACGAP1 |
| title_full | The Expression Regulation and Cancer-Promoting Roles of RACGAP1 |
| title_fullStr | The Expression Regulation and Cancer-Promoting Roles of RACGAP1 |
| title_full_unstemmed | The Expression Regulation and Cancer-Promoting Roles of RACGAP1 |
| title_short | The Expression Regulation and Cancer-Promoting Roles of RACGAP1 |
| title_sort | expression regulation and cancer promoting roles of racgap1 |
| topic | RACGAP1 Rho-GTPases ECT2 STAT3 |
| url | https://www.mdpi.com/2218-273X/15/1/3 |
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