A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery
Background: The aim of this study is to evaluate the value of intraoperative fluorescence imaging in assisting tumor localization and margin delineation during liver resection surgery, with the goal of improving the negative surgical margin rate and overall margin status. Methods: A systematic searc...
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001954 |
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| author | Fang Xie Qian Zhang Yuming Jia Kaijian Lei Hongru Yu Wei Zhang Li Li Daohong Kan |
| author_facet | Fang Xie Qian Zhang Yuming Jia Kaijian Lei Hongru Yu Wei Zhang Li Li Daohong Kan |
| author_sort | Fang Xie |
| collection | DOAJ |
| description | Background: The aim of this study is to evaluate the value of intraoperative fluorescence imaging in assisting tumor localization and margin delineation during liver resection surgery, with the goal of improving the negative surgical margin rate and overall margin status. Methods: A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for studies on the use of fluorescence imaging to aid in tumor localization and margin detection in liver cancer published between their inception and March 2025. After quality assessment of the included studies, a meta-analysis was performed using the STATA/SE 12.0 statistical software. Results: A total of 10 studies comprising 1097 patients were included in this meta-analysis. Compared to conventional liver resection, fluorescence-guided hepatectomy significantly increased the R0 resection rate [Odds ratio (OR) = 2.51, 95 % confidence intervals (CI): 1.65, 3.81, P = 0.000], with similar results observed in subgroup analyses. In addition, the fluorescence-guided hepatectomy group showed significantly less intraoperative blood loss [Weighted mean differences (WMD) = -100.53, 95 % CI:171.38, -29.68, P = 0.005]. However, no statistically significant differences were observed between the two groups in terms of margin distance, operative time, intraoperative transfusion, hospital stay, or overall complication rate. Conclusion: Fluorescence-guided hepatectomy can effectively increase the R0 resection rate and may contribute to reducing postoperative recurrence of liver cancer. However, further multicenter randomized controlled trials with larger sample sizes are needed to validate its impact on margin distance, operative time, intraoperative transfusion, hospital stay, and complication rates. |
| format | Article |
| id | doaj-art-97221a9ecfab4aa4a01e67dded80a020 |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-97221a9ecfab4aa4a01e67dded80a0202025-08-20T03:23:22ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410466310.1016/j.pdpdt.2025.104663A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgeryFang Xie0Qian Zhang1Yuming Jia2Kaijian Lei3Hongru Yu4Wei Zhang5Li Li6Daohong Kan7Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, ChinaDepartment of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, ChinaDepartment of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, ChinaDepartment of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, ChinaDepartment of Orthopaedics and Traumatology, Gongxian Hospital of Traditional Chinese Medicine, Yibin, Sichuan, ChinaDepartment of Rehabilitation, Gongxian Hospital of Traditional Chinese Medicine, Yibin, Sichuan, ChinaDepartment of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, China; Corresponding authors.Department of Burn and Plastic Surgery, The Second People's Hospital of Yibin, Yibin, Sichuan, China; Corresponding authors.Background: The aim of this study is to evaluate the value of intraoperative fluorescence imaging in assisting tumor localization and margin delineation during liver resection surgery, with the goal of improving the negative surgical margin rate and overall margin status. Methods: A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for studies on the use of fluorescence imaging to aid in tumor localization and margin detection in liver cancer published between their inception and March 2025. After quality assessment of the included studies, a meta-analysis was performed using the STATA/SE 12.0 statistical software. Results: A total of 10 studies comprising 1097 patients were included in this meta-analysis. Compared to conventional liver resection, fluorescence-guided hepatectomy significantly increased the R0 resection rate [Odds ratio (OR) = 2.51, 95 % confidence intervals (CI): 1.65, 3.81, P = 0.000], with similar results observed in subgroup analyses. In addition, the fluorescence-guided hepatectomy group showed significantly less intraoperative blood loss [Weighted mean differences (WMD) = -100.53, 95 % CI:171.38, -29.68, P = 0.005]. However, no statistically significant differences were observed between the two groups in terms of margin distance, operative time, intraoperative transfusion, hospital stay, or overall complication rate. Conclusion: Fluorescence-guided hepatectomy can effectively increase the R0 resection rate and may contribute to reducing postoperative recurrence of liver cancer. However, further multicenter randomized controlled trials with larger sample sizes are needed to validate its impact on margin distance, operative time, intraoperative transfusion, hospital stay, and complication rates.http://www.sciencedirect.com/science/article/pii/S1572100025001954Fluorescence navigationLiver cancerHepatectomySurgical marginMeta-analysis |
| spellingShingle | Fang Xie Qian Zhang Yuming Jia Kaijian Lei Hongru Yu Wei Zhang Li Li Daohong Kan A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery Photodiagnosis and Photodynamic Therapy Fluorescence navigation Liver cancer Hepatectomy Surgical margin Meta-analysis |
| title | A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery |
| title_full | A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery |
| title_fullStr | A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery |
| title_full_unstemmed | A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery |
| title_short | A meta-analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging-guided surgery |
| title_sort | meta analysis of surgical margin status and prognosis after precise resection of liver cancer using fluorescence imaging guided surgery |
| topic | Fluorescence navigation Liver cancer Hepatectomy Surgical margin Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025001954 |
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