Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation
Prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome. In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1043836 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556203913248768 |
|---|---|
| author | Xiaosu Zhao Xiangyu Zhao Mingrui Huo Qiaozhen Fan Xuying Pei Yu Wang Xiaohui Zhang Lanping Xu Xiaojun Huang Kaiyan Liu Yingjun Chang |
| author_facet | Xiaosu Zhao Xiangyu Zhao Mingrui Huo Qiaozhen Fan Xuying Pei Yu Wang Xiaohui Zhang Lanping Xu Xiaojun Huang Kaiyan Liu Yingjun Chang |
| author_sort | Xiaosu Zhao |
| collection | DOAJ |
| description | Prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome. In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT). For HLA antibody positive samples with a median fluorescent intensity (MFI) > 500, DSAs were further examined. A total of 390 patients (99.0%) achieved sustained myeloid engraftment. Of the 394 cases tested, 45 (11.4%) were DSA positive. The cumulative incidence of PT in this cohort of patients was 9.9 ± 1.5%. The incidence of PT was higher in patients with a MFI ≥ 1000 compared with those with a MFI < 1000 (16.8 ± 6.4% versus 7.4 ± 1.4%, P=0.05). Multivariate analysis showed that the presence of DSAs (MFI ≥ 1000) was correlated to PT (hazard ratio (HR) 3.262; 95% confidence interval (CI), 1.339–7.946; P=0.009) and transplant-related mortality (HR 2.320; 95% CI, 1.169–4.426; P=0.044). Our results, for the first time, suggest an association of DSAs with PT after unmanipulated HBMT. It would help screen out the suitable donor and guide intervention. This indicated that DSAs should be incorporated in the algorithm for unmanipulated HBMT. |
| format | Article |
| id | doaj-art-972139ff30d14d1fa3de254fea1504dc |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-972139ff30d14d1fa3de254fea1504dc2025-02-03T05:46:00ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/10438361043836Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell TransplantationXiaosu Zhao0Xiangyu Zhao1Mingrui Huo2Qiaozhen Fan3Xuying Pei4Yu Wang5Xiaohui Zhang6Lanping Xu7Xiaojun Huang8Kaiyan Liu9Yingjun Chang10Peking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaPeking University People’s Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044, ChinaProlonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome. In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT). For HLA antibody positive samples with a median fluorescent intensity (MFI) > 500, DSAs were further examined. A total of 390 patients (99.0%) achieved sustained myeloid engraftment. Of the 394 cases tested, 45 (11.4%) were DSA positive. The cumulative incidence of PT in this cohort of patients was 9.9 ± 1.5%. The incidence of PT was higher in patients with a MFI ≥ 1000 compared with those with a MFI < 1000 (16.8 ± 6.4% versus 7.4 ± 1.4%, P=0.05). Multivariate analysis showed that the presence of DSAs (MFI ≥ 1000) was correlated to PT (hazard ratio (HR) 3.262; 95% confidence interval (CI), 1.339–7.946; P=0.009) and transplant-related mortality (HR 2.320; 95% CI, 1.169–4.426; P=0.044). Our results, for the first time, suggest an association of DSAs with PT after unmanipulated HBMT. It would help screen out the suitable donor and guide intervention. This indicated that DSAs should be incorporated in the algorithm for unmanipulated HBMT.http://dx.doi.org/10.1155/2017/1043836 |
| spellingShingle | Xiaosu Zhao Xiangyu Zhao Mingrui Huo Qiaozhen Fan Xuying Pei Yu Wang Xiaohui Zhang Lanping Xu Xiaojun Huang Kaiyan Liu Yingjun Chang Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation Journal of Immunology Research |
| title | Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation |
| title_full | Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation |
| title_fullStr | Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation |
| title_full_unstemmed | Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation |
| title_short | Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation |
| title_sort | donor specific anti human leukocyte antigen antibodies predict prolonged isolated thrombocytopenia and inferior outcomes of haploidentical hematopoietic stem cell transplantation |
| url | http://dx.doi.org/10.1155/2017/1043836 |
| work_keys_str_mv | AT xiaosuzhao donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT xiangyuzhao donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT mingruihuo donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT qiaozhenfan donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT xuyingpei donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT yuwang donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT xiaohuizhang donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT lanpingxu donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT xiaojunhuang donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT kaiyanliu donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation AT yingjunchang donorspecificantihumanleukocyteantigenantibodiespredictprolongedisolatedthrombocytopeniaandinferioroutcomesofhaploidenticalhematopoieticstemcelltransplantation |