Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α<sub>IIb</sub>β<sub>3</sub> and Modulation of Fibrinogen

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α<sub>IIb</sub>β<sub>3</sub> and Modulation of Fibrinogen

In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arterial (i.e., 12%) oxygen concentrations cause a signif...

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Bibliographic Details
Main Authors: Sophie V. L. Leonard, Zoe Booth, Leigh Naylor-Adamson, Lewis Bibby, Katie S. Wraith, Giordano Pula, Monica Arman, Simon D. J. Calaminus
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
platelet
actin cytoskeleton
fibrinogen
oxygen
hypoxia
integrin function
Online Access:https://www.mdpi.com/2218-273X/15/4/501
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