Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes
BackgroundsMany pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension diso...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1468820/full |
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| author | Xingxi Lin Xingxi Lin Luhan Zhou Luhan Zhou Shuting Si Haoyue Cheng Haoyue Cheng Xialidan Alifu Xialidan Alifu Yiwen Qiu Yiwen Qiu Yan Zhuang Yan Zhuang Ye Huang Ye Huang Libi Zhang Libi Zhang Diliyaer Ainiwan Diliyaer Ainiwan Hui Liu Yunxian Yu Yunxian Yu |
| author_facet | Xingxi Lin Xingxi Lin Luhan Zhou Luhan Zhou Shuting Si Haoyue Cheng Haoyue Cheng Xialidan Alifu Xialidan Alifu Yiwen Qiu Yiwen Qiu Yan Zhuang Yan Zhuang Ye Huang Ye Huang Libi Zhang Libi Zhang Diliyaer Ainiwan Diliyaer Ainiwan Hui Liu Yunxian Yu Yunxian Yu |
| author_sort | Xingxi Lin |
| collection | DOAJ |
| description | BackgroundsMany pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.MethodsThe data was from the Zhoushan Maternal and Child Health Hospital electronic medical recorder system (EMRS) between 2015 and 2022. Multivariate linear regression model was used to analyze the association of GDM, HDP, and comorbidity with birth weight and gestational age, respectively. Multiple logistic regression model was used to analyze the association of GDM, HDP, and comorbidity with adverse birth outcomes.Results13645 pregnant women were included. GDM+HDP was significantly associated with a higher risk of composite adverse neonatal outcomes (OR=1.82, 95%CI: 1.02-3.04), including preterm birth, placenta previa, and/or neonatal jaundice, a higher risk of small for gestational age (SGA) (OR=2.2, 95% CI: 1.24 3.92) and large for gestational age (LGA) (OR=2.33, 95% CI: 1.64 3.31) compared with the normal group. Further analysis showed that HDP diagnosed in the 21-27th week comorbid with GDM had the lowest gestational age at delivery (β= -1.57, P=0.0002) and birth weight (β= -189.57, P=0.0138). Moreover, combined hyperglycemia (CH) comorbid with HDP had the strongest association with reduced gestational age (β= -0.83, P=0.0021).ConclusionPregnant women suffering from both GDM and HDP had a higher risk of adverse neonatal outcomes; hence, the prevent and treatment of GDM and HDP, especially their comorbidity, are very important for pregnant women. |
| format | Article |
| id | doaj-art-97175c7ef97d454a904aa85c78db3a42 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-97175c7ef97d454a904aa85c78db3a422025-08-20T02:34:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14688201468820Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomesXingxi Lin0Xingxi Lin1Luhan Zhou2Luhan Zhou3Shuting Si4Haoyue Cheng5Haoyue Cheng6Xialidan Alifu7Xialidan Alifu8Yiwen Qiu9Yiwen Qiu10Yan Zhuang11Yan Zhuang12Ye Huang13Ye Huang14Libi Zhang15Libi Zhang16Diliyaer Ainiwan17Diliyaer Ainiwan18Hui Liu19Yunxian Yu20Yunxian Yu21Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Health Care, Yiwu Maternity and Children Hospital (Yiwu Branch of Children’s Hospital Zhejiang University School of Medicine), Yiwu, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, ChinaBackgroundsMany pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.MethodsThe data was from the Zhoushan Maternal and Child Health Hospital electronic medical recorder system (EMRS) between 2015 and 2022. Multivariate linear regression model was used to analyze the association of GDM, HDP, and comorbidity with birth weight and gestational age, respectively. Multiple logistic regression model was used to analyze the association of GDM, HDP, and comorbidity with adverse birth outcomes.Results13645 pregnant women were included. GDM+HDP was significantly associated with a higher risk of composite adverse neonatal outcomes (OR=1.82, 95%CI: 1.02-3.04), including preterm birth, placenta previa, and/or neonatal jaundice, a higher risk of small for gestational age (SGA) (OR=2.2, 95% CI: 1.24 3.92) and large for gestational age (LGA) (OR=2.33, 95% CI: 1.64 3.31) compared with the normal group. Further analysis showed that HDP diagnosed in the 21-27th week comorbid with GDM had the lowest gestational age at delivery (β= -1.57, P=0.0002) and birth weight (β= -189.57, P=0.0138). Moreover, combined hyperglycemia (CH) comorbid with HDP had the strongest association with reduced gestational age (β= -0.83, P=0.0021).ConclusionPregnant women suffering from both GDM and HDP had a higher risk of adverse neonatal outcomes; hence, the prevent and treatment of GDM and HDP, especially their comorbidity, are very important for pregnant women.https://www.frontiersin.org/articles/10.3389/fendo.2024.1468820/fullgestational diabetes mellitushypertension disorderspregnancyadverse neonatal outcomescomorbidity |
| spellingShingle | Xingxi Lin Xingxi Lin Luhan Zhou Luhan Zhou Shuting Si Haoyue Cheng Haoyue Cheng Xialidan Alifu Xialidan Alifu Yiwen Qiu Yiwen Qiu Yan Zhuang Yan Zhuang Ye Huang Ye Huang Libi Zhang Libi Zhang Diliyaer Ainiwan Diliyaer Ainiwan Hui Liu Yunxian Yu Yunxian Yu Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes Frontiers in Endocrinology gestational diabetes mellitus hypertension disorders pregnancy adverse neonatal outcomes comorbidity |
| title | Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| title_full | Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| title_fullStr | Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| title_full_unstemmed | Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| title_short | Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| title_sort | association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes |
| topic | gestational diabetes mellitus hypertension disorders pregnancy adverse neonatal outcomes comorbidity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1468820/full |
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