Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats
ABSTRACT Introduction Substance use disorders, particularly alcohol use disorders, represent a significant public health problem, with adolescents particularly vulnerable to their adverse effects. This study examined the possible anxiolytic and antidepressant effects of biotin, a crucial vitamin for...
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Wiley
2025-03-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12523 |
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| author | Dawood Hossaini Adam Khan Alipour Meysam Sajjadi Mustafa Ansari Murtaza Haidary |
| author_facet | Dawood Hossaini Adam Khan Alipour Meysam Sajjadi Mustafa Ansari Murtaza Haidary |
| author_sort | Dawood Hossaini |
| collection | DOAJ |
| description | ABSTRACT Introduction Substance use disorders, particularly alcohol use disorders, represent a significant public health problem, with adolescents particularly vulnerable to their adverse effects. This study examined the possible anxiolytic and antidepressant effects of biotin, a crucial vitamin for brain function, in attenuating the behavioral and neurobiological changes associated with alcohol withdrawal in adolescent rats. Materials and Methods Sixty male Sprague–Dawley rats were exposed to a 20% ethanol solution for 21 days, followed by a 21‐day drug‐free period to assess long‐term behavioral and physiological changes. Behavioral assessments included the Open Field Test, Elevated Plus Maze, and Forced Swimming Test, administered post‐withdrawal to evaluate anxiety and depression behaviors. Additionally, biochemical analyses were performed to measure serotonin levels, monoamine oxidase‐A (MAO‐A) activity, and BDNF concentrations. Results The results indicate that ethanol withdrawal significantly induced anxiety‐ and depression‐like behavior in the rats. However, treatment with biotin, particularly at higher doses, effectively attenuated these withdrawal‐related behavioral changes. Mechanistically, biotin administration was found to regulate serotonin levels, monoamine oxidase activity, brain‐derived neurotrophic factor, and glial fibrillary acidic protein, and alleviate oxidative stress markers in cortical tissue. Discussion The results of this study suggest that biotin may have therapeutic potential for alleviating the negative effects of alcohol withdrawal, particularly those related to anxiety and depression. Further research is needed to elucidate the underlying mechanisms and examine the clinical effects of biotin supplementation for individuals undergoing alcohol withdrawal. |
| format | Article |
| id | doaj-art-970aaddd0a3f47cf80385e4e113cd437 |
| institution | DOAJ |
| issn | 2574-173X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
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| series | Neuropsychopharmacology Reports |
| spelling | doaj-art-970aaddd0a3f47cf80385e4e113cd4372025-08-20T02:40:48ZengWileyNeuropsychopharmacology Reports2574-173X2025-03-01451n/an/a10.1002/npr2.12523Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in RatsDawood Hossaini0Adam Khan Alipour1Meysam Sajjadi2Mustafa Ansari3Murtaza Haidary4Department of Biology and Microbiology, Faculty of Medical Laboratory Technology Khatam Al‐Nabieen University Kabul AfghanistanDepartment of Chemistry and Biochemistry, Faculty of Medical Laboratory Technology Khatam Al‐Nabieen University Kabul AfghanistanDepartment of Chemistry and Biochemistry, Faculty of Medical Laboratory Technology Khatam Al‐Nabieen University Kabul AfghanistanDepartment of Biology and Microbiology, Faculty of Medical Laboratory Technology Khatam Al‐Nabieen University Kabul AfghanistanDepartment of Biology and Microbiology, Faculty of Medical Laboratory Technology Khatam Al‐Nabieen University Kabul AfghanistanABSTRACT Introduction Substance use disorders, particularly alcohol use disorders, represent a significant public health problem, with adolescents particularly vulnerable to their adverse effects. This study examined the possible anxiolytic and antidepressant effects of biotin, a crucial vitamin for brain function, in attenuating the behavioral and neurobiological changes associated with alcohol withdrawal in adolescent rats. Materials and Methods Sixty male Sprague–Dawley rats were exposed to a 20% ethanol solution for 21 days, followed by a 21‐day drug‐free period to assess long‐term behavioral and physiological changes. Behavioral assessments included the Open Field Test, Elevated Plus Maze, and Forced Swimming Test, administered post‐withdrawal to evaluate anxiety and depression behaviors. Additionally, biochemical analyses were performed to measure serotonin levels, monoamine oxidase‐A (MAO‐A) activity, and BDNF concentrations. Results The results indicate that ethanol withdrawal significantly induced anxiety‐ and depression‐like behavior in the rats. However, treatment with biotin, particularly at higher doses, effectively attenuated these withdrawal‐related behavioral changes. Mechanistically, biotin administration was found to regulate serotonin levels, monoamine oxidase activity, brain‐derived neurotrophic factor, and glial fibrillary acidic protein, and alleviate oxidative stress markers in cortical tissue. Discussion The results of this study suggest that biotin may have therapeutic potential for alleviating the negative effects of alcohol withdrawal, particularly those related to anxiety and depression. Further research is needed to elucidate the underlying mechanisms and examine the clinical effects of biotin supplementation for individuals undergoing alcohol withdrawal.https://doi.org/10.1002/npr2.12523adolescentsalcohol withdrawalanxietycortexdepression |
| spellingShingle | Dawood Hossaini Adam Khan Alipour Meysam Sajjadi Mustafa Ansari Murtaza Haidary Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats Neuropsychopharmacology Reports adolescents alcohol withdrawal anxiety cortex depression |
| title | Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats |
| title_full | Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats |
| title_fullStr | Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats |
| title_full_unstemmed | Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats |
| title_short | Biotin Mitigates Alcohol Withdrawal‐Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats |
| title_sort | biotin mitigates alcohol withdrawal induced anxiety and depression by regulating serotonin metabolism bdnf inflammation and oxidative stress in rats |
| topic | adolescents alcohol withdrawal anxiety cortex depression |
| url | https://doi.org/10.1002/npr2.12523 |
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