Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the ad...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1216783 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562963351863296 |
|---|---|
| author | Almudena Gómez-Hernández Nuria Beneit Sabela Díaz-Castroverde Óscar Escribano |
| author_facet | Almudena Gómez-Hernández Nuria Beneit Sabela Díaz-Castroverde Óscar Escribano |
| author_sort | Almudena Gómez-Hernández |
| collection | DOAJ |
| description | This review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver. Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process. Furthermore, an inverse relationship between body mass index and brown adipose tissue activity has been described. For these reasons, in recent years, in order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans. These lines of knowledge are focused on the design of new drugs, or other approaches, in order to increase the mass and/or activity of brown adipose tissue or the browning process of beige cells from white adipose tissue. These new treatments may contribute not only to reduce obesity but also to prevent highly prevalent complications such as type 2 diabetes and other vascular alterations, such as hypertension or atherosclerosis. |
| format | Article |
| id | doaj-art-97088702ef1149f0a69a128ac127d120 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-97088702ef1149f0a69a128ac127d1202025-02-03T01:21:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/12167831216783Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular ComplicationsAlmudena Gómez-Hernández0Nuria Beneit1Sabela Díaz-Castroverde2Óscar Escribano3Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, SpainBiochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, SpainBiochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, SpainBiochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, Madrid, SpainThis review focuses on the contribution of white, brown, and perivascular adipose tissues to the pathophysiology of obesity and its associated metabolic and vascular complications. Weight gain in obesity generates excess of fat, usually visceral fat, and activates the inflammatory response in the adipocytes and then in other tissues such as liver. Therefore, low systemic inflammation responsible for insulin resistance contributes to atherosclerotic process. Furthermore, an inverse relationship between body mass index and brown adipose tissue activity has been described. For these reasons, in recent years, in order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans. These lines of knowledge are focused on the design of new drugs, or other approaches, in order to increase the mass and/or activity of brown adipose tissue or the browning process of beige cells from white adipose tissue. These new treatments may contribute not only to reduce obesity but also to prevent highly prevalent complications such as type 2 diabetes and other vascular alterations, such as hypertension or atherosclerosis.http://dx.doi.org/10.1155/2016/1216783 |
| spellingShingle | Almudena Gómez-Hernández Nuria Beneit Sabela Díaz-Castroverde Óscar Escribano Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications International Journal of Endocrinology |
| title | Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications |
| title_full | Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications |
| title_fullStr | Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications |
| title_full_unstemmed | Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications |
| title_short | Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications |
| title_sort | differential role of adipose tissues in obesity and related metabolic and vascular complications |
| url | http://dx.doi.org/10.1155/2016/1216783 |
| work_keys_str_mv | AT almudenagomezhernandez differentialroleofadiposetissuesinobesityandrelatedmetabolicandvascularcomplications AT nuriabeneit differentialroleofadiposetissuesinobesityandrelatedmetabolicandvascularcomplications AT sabeladiazcastroverde differentialroleofadiposetissuesinobesityandrelatedmetabolicandvascularcomplications AT oscarescribano differentialroleofadiposetissuesinobesityandrelatedmetabolicandvascularcomplications |