Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study
Abstract Introduction New pre‐exposure prophylaxis (PrEP) options, including event‐driven and long‐acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event‐driven and long‐acting injectable PrEP, along with associa...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Journal of the International AIDS Society |
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| Online Access: | https://doi.org/10.1002/jia2.26479 |
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| author | Laio Magno Beo Oliveira Leite Alexandre Grangeiro Lorenza Dezanet Fabiane Soares Inês Dourado |
| author_facet | Laio Magno Beo Oliveira Leite Alexandre Grangeiro Lorenza Dezanet Fabiane Soares Inês Dourado |
| author_sort | Laio Magno |
| collection | DOAJ |
| description | Abstract Introduction New pre‐exposure prophylaxis (PrEP) options, including event‐driven and long‐acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event‐driven and long‐acting injectable PrEP, along with associated factors, among adolescent and young men who have sex with men and transgender women. Methods A cross‐sectional study was conducted between December 2020 and February 2022 among men who have sex with men and young transgender women aged 15–20 years, who participated in a daily oral PrEP cohort study in Salvador and São Paulo, Brazil. Binomial logistic regression models analysed factors associated with the intention to use event‐driven and long‐acting injectable PrEP. Results A total of 1221 participants were enrolled in the cohort at the time of this analysis, with 597 responding to the survey. Awareness of event‐driven and long‐acting injectable PrEP was reported by 15.3% and 18.0% of participants, respectively. Intention to use event‐driven PrEP was reported by 56.4% of participants, while 81.5% expressed intention to use long‐acting injectable PrEP. Participants with lower and moderate adherence to daily oral PrEP were more likely to intend to use event‐driven PrEP (OR = 1.79; 95% CI: 1.04–3.08), whereas those who reported always or often using condoms in insertive anal sex with steady or casual partners were less likely to intend to use event‐driven PrEP (OR = 0.37; 95% CI: 0.15–0.90). For long‐acting injectable PrEP, participants with middle (OR = 1.93; 95% CI: 1.05–3.53) or low socio‐economic status (OR = 3.13; 95% CI: 1.30–7.51) and those reporting three or more casual partners in the past 3 months (OR = 2.25; 95% CI: 1.30–3.89) were more likely to intend to use long‐acting injectable PrEP. Conversely, participants who had never used daily oral PrEP were less likely to intend to use long‐acting injectable PrEP (OR = 0.31; 95% CI: 0.11–0.92). Conclusions Adolescents and young people in Brazil demonstrated a stronger preference for long‐acting injectable over event‐driven PrEP, with sexual behaviour patterns significantly influencing choices. Expanding prevention options may enhance PrEP uptake and adherence, improving HIV prevention strategies among adolescents and young adults. |
| format | Article |
| id | doaj-art-9706959d91864a6fb58d134712da3a68 |
| institution | Kabale University |
| issn | 1758-2652 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Journal of the International AIDS Society |
| spelling | doaj-art-9706959d91864a6fb58d134712da3a682025-08-20T03:31:37ZengWileyJournal of the International AIDS Society1758-26522025-07-0128S2n/an/a10.1002/jia2.26479Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional studyLaio Magno0Beo Oliveira Leite1Alexandre Grangeiro2Lorenza Dezanet3Fabiane Soares4Inês Dourado5Departamento de Ciências da Vida Universidade do Estado da Bahia Salvador BrazilInstituto de Saúde Coletiva Universidade Federal da Bahia Salvador BrazilFaculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto de Saúde Coletiva Universidade Federal da Bahia Salvador BrazilInstituto de Saúde Coletiva Universidade Federal da Bahia Salvador BrazilInstituto de Saúde Coletiva Universidade Federal da Bahia Salvador BrazilAbstract Introduction New pre‐exposure prophylaxis (PrEP) options, including event‐driven and long‐acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event‐driven and long‐acting injectable PrEP, along with associated factors, among adolescent and young men who have sex with men and transgender women. Methods A cross‐sectional study was conducted between December 2020 and February 2022 among men who have sex with men and young transgender women aged 15–20 years, who participated in a daily oral PrEP cohort study in Salvador and São Paulo, Brazil. Binomial logistic regression models analysed factors associated with the intention to use event‐driven and long‐acting injectable PrEP. Results A total of 1221 participants were enrolled in the cohort at the time of this analysis, with 597 responding to the survey. Awareness of event‐driven and long‐acting injectable PrEP was reported by 15.3% and 18.0% of participants, respectively. Intention to use event‐driven PrEP was reported by 56.4% of participants, while 81.5% expressed intention to use long‐acting injectable PrEP. Participants with lower and moderate adherence to daily oral PrEP were more likely to intend to use event‐driven PrEP (OR = 1.79; 95% CI: 1.04–3.08), whereas those who reported always or often using condoms in insertive anal sex with steady or casual partners were less likely to intend to use event‐driven PrEP (OR = 0.37; 95% CI: 0.15–0.90). For long‐acting injectable PrEP, participants with middle (OR = 1.93; 95% CI: 1.05–3.53) or low socio‐economic status (OR = 3.13; 95% CI: 1.30–7.51) and those reporting three or more casual partners in the past 3 months (OR = 2.25; 95% CI: 1.30–3.89) were more likely to intend to use long‐acting injectable PrEP. Conversely, participants who had never used daily oral PrEP were less likely to intend to use long‐acting injectable PrEP (OR = 0.31; 95% CI: 0.11–0.92). Conclusions Adolescents and young people in Brazil demonstrated a stronger preference for long‐acting injectable over event‐driven PrEP, with sexual behaviour patterns significantly influencing choices. Expanding prevention options may enhance PrEP uptake and adherence, improving HIV prevention strategies among adolescents and young adults.https://doi.org/10.1002/jia2.26479BrazilcabotegravirHIV preventionHIV pre‐exposure prophylaxissexual and gender minoritiesyouth health |
| spellingShingle | Laio Magno Beo Oliveira Leite Alexandre Grangeiro Lorenza Dezanet Fabiane Soares Inês Dourado Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study Journal of the International AIDS Society Brazil cabotegravir HIV prevention HIV pre‐exposure prophylaxis sexual and gender minorities youth health |
| title | Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study |
| title_full | Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study |
| title_fullStr | Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study |
| title_full_unstemmed | Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study |
| title_short | Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross‐sectional study |
| title_sort | awareness and intention to use event driven and long acting injectable pre exposure prophylaxis among adolescent and young men who have sex with men and transgender women in brazil a cross sectional study |
| topic | Brazil cabotegravir HIV prevention HIV pre‐exposure prophylaxis sexual and gender minorities youth health |
| url | https://doi.org/10.1002/jia2.26479 |
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