Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships
The skeletal muscle, one of the largest tissues in mammals, plays a crucial role in maintaining body movement and energy metabolism. Dysfunction or damage to the skeletal muscle can lead to various muscle diseases, such as muscular dystrophy, myasthenia, and others. The myofiber presents the fundame...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1602607/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850132049689575424 |
|---|---|
| author | Jing Zhao Xu Du Wei Fang Hongxia Zhu Binglin Yue |
| author_facet | Jing Zhao Xu Du Wei Fang Hongxia Zhu Binglin Yue |
| author_sort | Jing Zhao |
| collection | DOAJ |
| description | The skeletal muscle, one of the largest tissues in mammals, plays a crucial role in maintaining body movement and energy metabolism. Dysfunction or damage to the skeletal muscle can lead to various muscle diseases, such as muscular dystrophy, myasthenia, and others. The myofiber presents the fundamental structural unit of the skeletal muscle, and research on its structure and biological function is of great significance. Here, we review the latest progress in the structural and functional aspects of the myofiber, focusing on myofibril, the sarcoplasmic reticulum, mitochondria, and the cytoskeleton. The basic properties and dynamic interactions of a large number of muscle proteins have been described in detail, including the scaffold construction of core protein components and the fine-tuning of secondary protein components with functional redundancy. This overview provides new insights into skeletal muscle pathophysiology. |
| format | Article |
| id | doaj-art-9701ac417b8e404f97c323c202f22f8d |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-9701ac417b8e404f97c323c202f22f8d2025-08-20T02:32:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.16026071602607Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationshipsJing Zhao0Xu Du1Wei Fang2Hongxia Zhu3Binglin Yue4Department of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, ChinaThe skeletal muscle, one of the largest tissues in mammals, plays a crucial role in maintaining body movement and energy metabolism. Dysfunction or damage to the skeletal muscle can lead to various muscle diseases, such as muscular dystrophy, myasthenia, and others. The myofiber presents the fundamental structural unit of the skeletal muscle, and research on its structure and biological function is of great significance. Here, we review the latest progress in the structural and functional aspects of the myofiber, focusing on myofibril, the sarcoplasmic reticulum, mitochondria, and the cytoskeleton. The basic properties and dynamic interactions of a large number of muscle proteins have been described in detail, including the scaffold construction of core protein components and the fine-tuning of secondary protein components with functional redundancy. This overview provides new insights into skeletal muscle pathophysiology.https://www.frontiersin.org/articles/10.3389/fcell.2025.1602607/fullskeletal myofibermyofibrilsarcoplasmic reticulummitochondriacytoskeleton |
| spellingShingle | Jing Zhao Xu Du Wei Fang Hongxia Zhu Binglin Yue Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships Frontiers in Cell and Developmental Biology skeletal myofiber myofibril sarcoplasmic reticulum mitochondria cytoskeleton |
| title | Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships |
| title_full | Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships |
| title_fullStr | Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships |
| title_full_unstemmed | Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships |
| title_short | Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships |
| title_sort | architecture and molecular machinery of skeletal myofibers a systematic review of the structure function relationships |
| topic | skeletal myofiber myofibril sarcoplasmic reticulum mitochondria cytoskeleton |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1602607/full |
| work_keys_str_mv | AT jingzhao architectureandmolecularmachineryofskeletalmyofibersasystematicreviewofthestructurefunctionrelationships AT xudu architectureandmolecularmachineryofskeletalmyofibersasystematicreviewofthestructurefunctionrelationships AT weifang architectureandmolecularmachineryofskeletalmyofibersasystematicreviewofthestructurefunctionrelationships AT hongxiazhu architectureandmolecularmachineryofskeletalmyofibersasystematicreviewofthestructurefunctionrelationships AT binglinyue architectureandmolecularmachineryofskeletalmyofibersasystematicreviewofthestructurefunctionrelationships |