Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction
Background: Esophagogastric junction outflow obstruction (EGJOO) is a manometric diagnosis based on Chicago Classification version 4.0 (CC4.0) that requires confirmatory testing for clinical relevancy. However, it is still unclear which patients will respond to therapy. Objectives: To evaluate manom...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/17562848241306128 |
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| author | Alexandra Strauss Starling Shivani U. Thanawala Claire A. Beveridge Gary W. Falk Kristle L. Lynch |
| author_facet | Alexandra Strauss Starling Shivani U. Thanawala Claire A. Beveridge Gary W. Falk Kristle L. Lynch |
| author_sort | Alexandra Strauss Starling |
| collection | DOAJ |
| description | Background: Esophagogastric junction outflow obstruction (EGJOO) is a manometric diagnosis based on Chicago Classification version 4.0 (CC4.0) that requires confirmatory testing for clinical relevancy. However, it is still unclear which patients will respond to therapy. Objectives: To evaluate manometric and clinical predictors of abnormal confirmatory testing for patients with EGJOO. Design: This was a prospective observational study of patients with manometric EGJOO and chest pain or dysphagia who underwent confirmatory testing. Methods: Patients with EGJOO on manometry were enrolled and underwent timed barium esophagram or endoFLIP. A subset of patients was given validated surveys, including Eckardt scores (ES) and PROMIS-10. Results: For patients with a CC4.0 EGJOO diagnosis, abnormal peristalsis (OR = 7.0, 95% CI = 1.01–44.6, p = 0.04) and increases in ES (OR = 2.34 95% CI = 1.13–4.86, p = 0.02) were associated with positive confirmatory testing. Conclusion: Patients with potentially actionable EGJOO were more likely to have an abnormal peristaltic subtype of EGJOO or higher ES. |
| format | Article |
| id | doaj-art-96ff154e04754d8f9d54f76525730f38 |
| institution | DOAJ |
| issn | 1756-2848 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj-art-96ff154e04754d8f9d54f76525730f382025-08-20T02:40:30ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482024-12-011710.1177/17562848241306128Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstructionAlexandra Strauss StarlingShivani U. ThanawalaClaire A. BeveridgeGary W. FalkKristle L. LynchBackground: Esophagogastric junction outflow obstruction (EGJOO) is a manometric diagnosis based on Chicago Classification version 4.0 (CC4.0) that requires confirmatory testing for clinical relevancy. However, it is still unclear which patients will respond to therapy. Objectives: To evaluate manometric and clinical predictors of abnormal confirmatory testing for patients with EGJOO. Design: This was a prospective observational study of patients with manometric EGJOO and chest pain or dysphagia who underwent confirmatory testing. Methods: Patients with EGJOO on manometry were enrolled and underwent timed barium esophagram or endoFLIP. A subset of patients was given validated surveys, including Eckardt scores (ES) and PROMIS-10. Results: For patients with a CC4.0 EGJOO diagnosis, abnormal peristalsis (OR = 7.0, 95% CI = 1.01–44.6, p = 0.04) and increases in ES (OR = 2.34 95% CI = 1.13–4.86, p = 0.02) were associated with positive confirmatory testing. Conclusion: Patients with potentially actionable EGJOO were more likely to have an abnormal peristaltic subtype of EGJOO or higher ES.https://doi.org/10.1177/17562848241306128 |
| spellingShingle | Alexandra Strauss Starling Shivani U. Thanawala Claire A. Beveridge Gary W. Falk Kristle L. Lynch Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction Therapeutic Advances in Gastroenterology |
| title | Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| title_full | Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| title_fullStr | Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| title_full_unstemmed | Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| title_short | Look above the IRP: predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| title_sort | look above the irp predicting abnormal confirmatory testing in patients with esophagogastric junction outflow obstruction |
| url | https://doi.org/10.1177/17562848241306128 |
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