Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs
Skeletal muscle (SKM) has crucial roles in locomotor activity and posture within the body and also functions have been recognized as an actively secretory organ. Numerous bioactive molecules are secreted by SKM and transported by extracellular vesicles (EVs), a novel class of mediators of communicat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1501957/full |
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| author | Jiajie Jia Jiajie Jia Lu Wang Lu Wang Yue Zhou Peng Zhang Xiaoping Chen |
| author_facet | Jiajie Jia Jiajie Jia Lu Wang Lu Wang Yue Zhou Peng Zhang Xiaoping Chen |
| author_sort | Jiajie Jia |
| collection | DOAJ |
| description | Skeletal muscle (SKM) has crucial roles in locomotor activity and posture within the body and also functions have been recognized as an actively secretory organ. Numerous bioactive molecules are secreted by SKM and transported by extracellular vesicles (EVs), a novel class of mediators of communication between cells and organs that contain various types of cargo molecules including lipids, proteins and nucleic acids. SKM-derived EVs (SKM-EVs) are intercellular communicators with significant roles in the crosstalk between SKM and other organs. In this review, we briefly describe the biological characteristics, composition, and uptake mechanisms of EVs, particularly exosomes, comprehensively summarize the regulatory effects of SKM-EVs on the function of, which include myogenesis, muscle repair and regeneration, as well as metabolic regulation. Furthermore, we explore the impact of SKM- EVs on various organs including bone, the cardiovascular system, adipose tissue, and nervous system. As emerging evidence suggests that SKM-EVs are involved in the development and regulation of type 2 diabetes (T2D), systemic inflammation, and other chronic diseases, we also highlight the potential of SKM-EVs as therapeutic targets and diagnostic biomarkers, emphasizing the need for further research to elucidate the complex mechanisms underlying intercellular communication in physiological and pathological contexts. |
| format | Article |
| id | doaj-art-96fe1f98806b4f48b964e55cb96ea744 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-96fe1f98806b4f48b964e55cb96ea7442025-08-20T02:44:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-01-011510.3389/fphys.2024.15019571501957Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organsJiajie Jia0Jiajie Jia1Lu Wang2Lu Wang3Yue Zhou4Peng Zhang5Xiaoping Chen6National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaNational Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, ChinaNational Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing, ChinaSkeletal muscle (SKM) has crucial roles in locomotor activity and posture within the body and also functions have been recognized as an actively secretory organ. Numerous bioactive molecules are secreted by SKM and transported by extracellular vesicles (EVs), a novel class of mediators of communication between cells and organs that contain various types of cargo molecules including lipids, proteins and nucleic acids. SKM-derived EVs (SKM-EVs) are intercellular communicators with significant roles in the crosstalk between SKM and other organs. In this review, we briefly describe the biological characteristics, composition, and uptake mechanisms of EVs, particularly exosomes, comprehensively summarize the regulatory effects of SKM-EVs on the function of, which include myogenesis, muscle repair and regeneration, as well as metabolic regulation. Furthermore, we explore the impact of SKM- EVs on various organs including bone, the cardiovascular system, adipose tissue, and nervous system. As emerging evidence suggests that SKM-EVs are involved in the development and regulation of type 2 diabetes (T2D), systemic inflammation, and other chronic diseases, we also highlight the potential of SKM-EVs as therapeutic targets and diagnostic biomarkers, emphasizing the need for further research to elucidate the complex mechanisms underlying intercellular communication in physiological and pathological contexts.https://www.frontiersin.org/articles/10.3389/fphys.2024.1501957/fullextracellular vesiclesskeletal musclemicroRNAscrosstalkcargo |
| spellingShingle | Jiajie Jia Jiajie Jia Lu Wang Lu Wang Yue Zhou Peng Zhang Xiaoping Chen Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs Frontiers in Physiology extracellular vesicles skeletal muscle microRNAs crosstalk cargo |
| title | Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| title_full | Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| title_fullStr | Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| title_full_unstemmed | Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| title_short | Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| title_sort | muscle derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs |
| topic | extracellular vesicles skeletal muscle microRNAs crosstalk cargo |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1501957/full |
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