Postnatal environment affects auditory development and sensorimotor gating in a rat model for autism spectrum disorder

Postnatal environment affects auditory development and sensorimotor gating in a rat model for autism spectrum disorder

The homozygous Cntnap2 knockout (KO) rat is a well-established genetic model for neurodevelopmental disorders, exhibiting core features of autism spectrum disorder (ASD), including impaired sensory processing and sensorimotor gating. Recent findings indicate that the severity of ASD-like phenotypes...

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Bibliographic Details
Main Authors: Ella Elizabeth Doornaert, Alaa El-Cheikh Mohamad, Gurwinder Johal, Brian Leonard Allman, Dorit Möhrle, Susanne Schmid
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neuroscience
Subjects:
CNTNAP2
auditory processing
startle
prepulse inhibition
gap detection
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1565919/full
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