Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS
Background: Several studies on patients with Alzheimer's disease (AD) have used transcranial direct current stimulation (tDCS) to enhance neural excitability in the left dorsolateral prefrontal cortex (lDLPFC). Interindividual differences in brain anatomy in AD patients pose a challenge to effi...
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Elsevier
2023-06-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266695602300017X |
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| author | Ingrid Daae Rasmussen Matthias Mittner Nya Mehnwolo Boayue Gábor Csifcsák Per M. Aslaksen |
| author_facet | Ingrid Daae Rasmussen Matthias Mittner Nya Mehnwolo Boayue Gábor Csifcsák Per M. Aslaksen |
| author_sort | Ingrid Daae Rasmussen |
| collection | DOAJ |
| description | Background: Several studies on patients with Alzheimer's disease (AD) have used transcranial direct current stimulation (tDCS) to enhance neural excitability in the left dorsolateral prefrontal cortex (lDLPFC). Interindividual differences in brain anatomy in AD patients pose a challenge to efficiently target the lDLPFC using scalp-based coordinates, calling for new and more precise tDCS protocols. Objective: The purpose of this study was to explore how AD-related neuropathology affects the tDCS-induced electric field (EF) across different DLPFC montages using computational modeling. Method: Forty-eight realistic head models were created from structural magnetic resonance scans of AD patients and healthy controls collected from a publicly available database. We compared the tDCS-induced EF in different montages applied in the literature, in addition to a high definition (HD)-tDCS montage centered at electrode F3. Results: There was an overall global reduction in EF strength in the patient group, probably due to structural alterations that were also identified in the patient group. A widespread distribution of the EF was found across the frontal lobe for bipolar montages, while HD-tDCS yielded more focal stimulation, mainly restricted to the lDLPFC. Minor differences in the EF distribution were found when comparing the HD-tDCS montages. Conclusion: Neurodegenerative alterations present in patients with AD affect the magnitude, distribution and variability of the EF. HD-tDCS montages provide more focal stimulation of the target area, compared to bipolar montages with to pronounced group differences between AD patients and healthy matched controls. This finding poses substantial limitations to the comparison of cognitive effects of tDCS both between patients and controls and within patients at different stages of disease progression. |
| format | Article |
| id | doaj-art-96fa411ccf89459b9b5ebd57679ecefb |
| institution | Kabale University |
| issn | 2666-9560 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-96fa411ccf89459b9b5ebd57679ecefb2025-08-20T03:37:09ZengElsevierNeuroImage: Reports2666-95602023-06-013210017210.1016/j.ynirp.2023.100172Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCSIngrid Daae Rasmussen0Matthias Mittner1Nya Mehnwolo Boayue2Gábor Csifcsák3Per M. Aslaksen4Department of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, UiT the Artic University of Norway, Tromsø, Norway; Department of Geropsychiatry, University Hospital of North Norway, Norway; Corresponding author. UiT The Arctic University of Norway, Huginbakken 32, N-9037, Norway.Department of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, UiT the Artic University of Norway, Tromsø, NorwayDepartment of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, UiT the Artic University of Norway, Tromsø, NorwayDepartment of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, UiT the Artic University of Norway, Tromsø, NorwayDepartment of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, UiT the Artic University of Norway, Tromsø, Norway; Department of Child and Adolescent Psychiatry, University Hospital of North Norway, Tromsø, NorwayBackground: Several studies on patients with Alzheimer's disease (AD) have used transcranial direct current stimulation (tDCS) to enhance neural excitability in the left dorsolateral prefrontal cortex (lDLPFC). Interindividual differences in brain anatomy in AD patients pose a challenge to efficiently target the lDLPFC using scalp-based coordinates, calling for new and more precise tDCS protocols. Objective: The purpose of this study was to explore how AD-related neuropathology affects the tDCS-induced electric field (EF) across different DLPFC montages using computational modeling. Method: Forty-eight realistic head models were created from structural magnetic resonance scans of AD patients and healthy controls collected from a publicly available database. We compared the tDCS-induced EF in different montages applied in the literature, in addition to a high definition (HD)-tDCS montage centered at electrode F3. Results: There was an overall global reduction in EF strength in the patient group, probably due to structural alterations that were also identified in the patient group. A widespread distribution of the EF was found across the frontal lobe for bipolar montages, while HD-tDCS yielded more focal stimulation, mainly restricted to the lDLPFC. Minor differences in the EF distribution were found when comparing the HD-tDCS montages. Conclusion: Neurodegenerative alterations present in patients with AD affect the magnitude, distribution and variability of the EF. HD-tDCS montages provide more focal stimulation of the target area, compared to bipolar montages with to pronounced group differences between AD patients and healthy matched controls. This finding poses substantial limitations to the comparison of cognitive effects of tDCS both between patients and controls and within patients at different stages of disease progression.http://www.sciencedirect.com/science/article/pii/S266695602300017XtDCSTranscranial direct current stimulationAlzheimer's diseaseComputational modelingtDCS-induced electric fieldNoninvasive brain stimulation |
| spellingShingle | Ingrid Daae Rasmussen Matthias Mittner Nya Mehnwolo Boayue Gábor Csifcsák Per M. Aslaksen Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS NeuroImage: Reports tDCS Transcranial direct current stimulation Alzheimer's disease Computational modeling tDCS-induced electric field Noninvasive brain stimulation |
| title | Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS |
| title_full | Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS |
| title_fullStr | Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS |
| title_full_unstemmed | Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS |
| title_short | Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS |
| title_sort | tracking the current in the alzheimer s brain systematic differences between patients and healthy controls in the electric field induced by tdcs |
| topic | tDCS Transcranial direct current stimulation Alzheimer's disease Computational modeling tDCS-induced electric field Noninvasive brain stimulation |
| url | http://www.sciencedirect.com/science/article/pii/S266695602300017X |
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