A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats

A transient blood IL-17 increase triggers neuroinflammation in cerebellum and motor incoordination in hyperammonemic rats

Abstract Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with motor incoordination which is reproduced in hyperammonemic rats. Hyperammonemia induces peripheral inflammation which triggers neuroinflammation and enhanced GABAergic neurotransmission in cerebellum and motor...

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Bibliographic Details
Main Authors: Yaiza M. Arenas, Carmina Montoliu, Marta Llansola, Vicente Felipo
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Neuroinflammation
Subjects:
Hyperammonemia
Hepatic encephalopathy
Motor incoordination
IL-17
Blood–brain barrier
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03310-5
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