Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2
Neurotrophic keratitis (neurotrophic keratopathy) (NTC) is a degenerative disease of the cornea accompanied with neurogenic inflammation. It is caused by a loss of sensitive innervation of the trigeminal nerve. Therapeutic measures are mainly reduced to maintenance therapy (antiseptics, artificial t...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2022-07-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1842 |
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| author | E. A. Kasparova N. R. Marchenko |
| author_facet | E. A. Kasparova N. R. Marchenko |
| author_sort | E. A. Kasparova |
| collection | DOAJ |
| description | Neurotrophic keratitis (neurotrophic keratopathy) (NTC) is a degenerative disease of the cornea accompanied with neurogenic inflammation. It is caused by a loss of sensitive innervation of the trigeminal nerve. Therapeutic measures are mainly reduced to maintenance therapy (antiseptics, artificial tears, corneal protectors), which does not affect the cause of the disease. The most affordable and updated therapy is the long-term topical use of auto- or heterologous serum. Recently developed specific approaches to the treatment of NTK — local therapy with recombinant nerve growth factor Cenegermin and corneal neurotization are aimed at the pathogenetic links of the disease and can restore the innervation and sensitivity of the cornea. |
| format | Article |
| id | doaj-art-96f69abb0d2b4d09a65300a81264f087 |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-96f69abb0d2b4d09a65300a81264f0872025-08-20T03:38:18ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452022-07-0119226527110.18008/1816-5095-2022-2-265-271895Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2E. A. Kasparova0N. R. Marchenko1Research Institute of Eye Diseases SciencesResearch Institute of Eye Diseases SciencesNeurotrophic keratitis (neurotrophic keratopathy) (NTC) is a degenerative disease of the cornea accompanied with neurogenic inflammation. It is caused by a loss of sensitive innervation of the trigeminal nerve. Therapeutic measures are mainly reduced to maintenance therapy (antiseptics, artificial tears, corneal protectors), which does not affect the cause of the disease. The most affordable and updated therapy is the long-term topical use of auto- or heterologous serum. Recently developed specific approaches to the treatment of NTK — local therapy with recombinant nerve growth factor Cenegermin and corneal neurotization are aimed at the pathogenetic links of the disease and can restore the innervation and sensitivity of the cornea.https://www.ophthalmojournal.com/opht/article/view/1842neurotrophic keratitisneurotrophic keratopathypersistent epithelial defectcorneal erosioncorneal ulcercorneal meltingcorneal nervesrecombinant nerve growth factorinsulinneurogenic inflammationautologous serumcorneal neurotization |
| spellingShingle | E. A. Kasparova N. R. Marchenko Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 Oftalʹmologiâ neurotrophic keratitis neurotrophic keratopathy persistent epithelial defect corneal erosion corneal ulcer corneal melting corneal nerves recombinant nerve growth factor insulin neurogenic inflammation autologous serum corneal neurotization |
| title | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 |
| title_full | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 |
| title_fullStr | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 |
| title_full_unstemmed | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 |
| title_short | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 2 |
| title_sort | neurotrophic keratitis etiology pathogenesis clinical manifestations review part 2 |
| topic | neurotrophic keratitis neurotrophic keratopathy persistent epithelial defect corneal erosion corneal ulcer corneal melting corneal nerves recombinant nerve growth factor insulin neurogenic inflammation autologous serum corneal neurotization |
| url | https://www.ophthalmojournal.com/opht/article/view/1842 |
| work_keys_str_mv | AT eakasparova neurotrophickeratitisetiologypathogenesisclinicalmanifestationsreviewpart2 AT nrmarchenko neurotrophickeratitisetiologypathogenesisclinicalmanifestationsreviewpart2 |