Development of a New Tool for 3D Modeling for Regenerative Medicine
The effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis of the three-dimensional (3D) distribution of target drugs within the tissue. Here, we present a ne...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2011/236854 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403910701187072 |
|---|---|
| author | Filippo Mattoli Roberto Tiribuzi Francesco D'Angelo Ilaria di Girolamo Mattia Quattrocelli Simona Montesano Lucia Crispoltoni Vasileios Oikonomou Maria Gabriella Cusella De Angelis Peggy Marconi Antonio Orlacchio Maurilio Sampaolesi Sabata Martino Aldo Orlacchio |
| author_facet | Filippo Mattoli Roberto Tiribuzi Francesco D'Angelo Ilaria di Girolamo Mattia Quattrocelli Simona Montesano Lucia Crispoltoni Vasileios Oikonomou Maria Gabriella Cusella De Angelis Peggy Marconi Antonio Orlacchio Maurilio Sampaolesi Sabata Martino Aldo Orlacchio |
| author_sort | Filippo Mattoli |
| collection | DOAJ |
| description | The effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis of the three-dimensional (3D) distribution of target drugs within the tissue. Here, we present a new computational procedure able to overcome the limitations of visual analysis emerging by the examination of a molecular signal within images of serial tissue/organ sections by using the conventional techniques. Together with the 3D anatomical reconstitution of the tissue/organ, our framework allows the detection of signals of different origins (e.g., marked generic molecules, colorimetric, or fluorimetric substrates for enzymes; microRNA; recombinant protein). Remarkably, the application does not require the employment of specific tracking reagents for the imaging analysis. We report two different representative applications: the first shows the reconstruction of a 3D model of mouse brain with the analysis of the distribution of the β-Galactosidase, the second shows the reconstruction of a 3D mouse heart with the measurement of the cardiac volume. |
| format | Article |
| id | doaj-art-96f0f64ae6594aec8a8570ac4a970ead |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-96f0f64ae6594aec8a8570ac4a970ead2025-08-20T03:37:09ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/236854236854Development of a New Tool for 3D Modeling for Regenerative MedicineFilippo Mattoli0Roberto Tiribuzi1Francesco D'Angelo2Ilaria di Girolamo3Mattia Quattrocelli4Simona Montesano5Lucia Crispoltoni6Vasileios Oikonomou7Maria Gabriella Cusella De Angelis8Peggy Marconi9Antonio Orlacchio10Maurilio Sampaolesi11Sabata Martino12Aldo Orlacchio13Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale, Sezione Anatomia Umana, Università di Pavia, 27100 Pavia, ItalyDipartimento di Medicina Sperimentale e Diagnostica, Sezione di Microbiologia, Università degli Studi di Ferrara, 44121 Ferrara, ItalyLaboratorio di Neurogenetica, CERC-IRCCS Santa Lucia, Rome, ItalyTranslational Cardiomyology Laboratory, SCIL K.U. Leuven, 3000 Leuven, BelgiumDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyDipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica e Biologia Molecolare, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, ItalyThe effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis of the three-dimensional (3D) distribution of target drugs within the tissue. Here, we present a new computational procedure able to overcome the limitations of visual analysis emerging by the examination of a molecular signal within images of serial tissue/organ sections by using the conventional techniques. Together with the 3D anatomical reconstitution of the tissue/organ, our framework allows the detection of signals of different origins (e.g., marked generic molecules, colorimetric, or fluorimetric substrates for enzymes; microRNA; recombinant protein). Remarkably, the application does not require the employment of specific tracking reagents for the imaging analysis. We report two different representative applications: the first shows the reconstruction of a 3D model of mouse brain with the analysis of the distribution of the β-Galactosidase, the second shows the reconstruction of a 3D mouse heart with the measurement of the cardiac volume.http://dx.doi.org/10.1155/2011/236854 |
| spellingShingle | Filippo Mattoli Roberto Tiribuzi Francesco D'Angelo Ilaria di Girolamo Mattia Quattrocelli Simona Montesano Lucia Crispoltoni Vasileios Oikonomou Maria Gabriella Cusella De Angelis Peggy Marconi Antonio Orlacchio Maurilio Sampaolesi Sabata Martino Aldo Orlacchio Development of a New Tool for 3D Modeling for Regenerative Medicine International Journal of Biomedical Imaging |
| title | Development of a New Tool for 3D Modeling for Regenerative Medicine |
| title_full | Development of a New Tool for 3D Modeling for Regenerative Medicine |
| title_fullStr | Development of a New Tool for 3D Modeling for Regenerative Medicine |
| title_full_unstemmed | Development of a New Tool for 3D Modeling for Regenerative Medicine |
| title_short | Development of a New Tool for 3D Modeling for Regenerative Medicine |
| title_sort | development of a new tool for 3d modeling for regenerative medicine |
| url | http://dx.doi.org/10.1155/2011/236854 |
| work_keys_str_mv | AT filippomattoli developmentofanewtoolfor3dmodelingforregenerativemedicine AT robertotiribuzi developmentofanewtoolfor3dmodelingforregenerativemedicine AT francescodangelo developmentofanewtoolfor3dmodelingforregenerativemedicine AT ilariadigirolamo developmentofanewtoolfor3dmodelingforregenerativemedicine AT mattiaquattrocelli developmentofanewtoolfor3dmodelingforregenerativemedicine AT simonamontesano developmentofanewtoolfor3dmodelingforregenerativemedicine AT luciacrispoltoni developmentofanewtoolfor3dmodelingforregenerativemedicine AT vasileiosoikonomou developmentofanewtoolfor3dmodelingforregenerativemedicine AT mariagabriellacuselladeangelis developmentofanewtoolfor3dmodelingforregenerativemedicine AT peggymarconi developmentofanewtoolfor3dmodelingforregenerativemedicine AT antonioorlacchio developmentofanewtoolfor3dmodelingforregenerativemedicine AT mauriliosampaolesi developmentofanewtoolfor3dmodelingforregenerativemedicine AT sabatamartino developmentofanewtoolfor3dmodelingforregenerativemedicine AT aldoorlacchio developmentofanewtoolfor3dmodelingforregenerativemedicine |