Churg-Strauss syndrome: A case report
Introduction. Churg-Strauss syndrome (CSS) is an allergic granulomatous angiitis, a rare disease of small and medium arteries and veins, associated with the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). According to the American College of Rheumatology (ACR), there are...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300022D.pdf |
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| author | Dinić Miroslav Ž. Kandolf-Sekulović Lidija Zolotarevski Lidija Zečević Radoš D. |
| author_facet | Dinić Miroslav Ž. Kandolf-Sekulović Lidija Zolotarevski Lidija Zečević Radoš D. |
| author_sort | Dinić Miroslav Ž. |
| collection | DOAJ |
| description | Introduction. Churg-Strauss syndrome (CSS) is an allergic granulomatous angiitis, a rare disease of small and medium arteries and veins, associated with the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). According to the American College of Rheumatology (ACR), there are four or more criteria out of six for the diagnosis: asthma, eosinophilia (> 10% in peripheral blood), paranasal sinusitis, pulmonary infiltrates, histological evidence of vasculitis with extravascular eosinophils, and mononeuritis multiplex or polyneuropathy. Case report. We reported a female patient, aged 80 years, with asthma for many decades and repeatedly verified eosinophilia in peripheral blood, in which CSS was suspected only after the occurrence of skin changes in the form of vesicles, vesiculopustule, purpuric macula, papule and petechiae. Further tests verified pulmonary infiltrates, paranasal sinusitis, extravascular eosinophils on histopathologic sample of skin tissue, and polyneuropathy. The treatment started with methylprednisolone (60 mg/d, with decreasing doses), and continued with pulse doses of cyclophosphamide (800 mg once monthly), also corticosteroid ointment for skin lesions. Conclusion. Despite long-standing pulmonary symptoms and laboratory findings of eosinophilia, the appearance of skin changes raised suspicion of possible CSS. Skin changes resolved and the patient was reffered to rheumatologist. |
| format | Article |
| id | doaj-art-96eada7da8b247e98bb72d50de4e8f54 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-96eada7da8b247e98bb72d50de4e8f542025-08-20T03:37:30ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170770070310.2298/VSP130111022DChurg-Strauss syndrome: A case reportDinić Miroslav Ž.Kandolf-Sekulović LidijaZolotarevski LidijaZečević Radoš D.Introduction. Churg-Strauss syndrome (CSS) is an allergic granulomatous angiitis, a rare disease of small and medium arteries and veins, associated with the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). According to the American College of Rheumatology (ACR), there are four or more criteria out of six for the diagnosis: asthma, eosinophilia (> 10% in peripheral blood), paranasal sinusitis, pulmonary infiltrates, histological evidence of vasculitis with extravascular eosinophils, and mononeuritis multiplex or polyneuropathy. Case report. We reported a female patient, aged 80 years, with asthma for many decades and repeatedly verified eosinophilia in peripheral blood, in which CSS was suspected only after the occurrence of skin changes in the form of vesicles, vesiculopustule, purpuric macula, papule and petechiae. Further tests verified pulmonary infiltrates, paranasal sinusitis, extravascular eosinophils on histopathologic sample of skin tissue, and polyneuropathy. The treatment started with methylprednisolone (60 mg/d, with decreasing doses), and continued with pulse doses of cyclophosphamide (800 mg once monthly), also corticosteroid ointment for skin lesions. Conclusion. Despite long-standing pulmonary symptoms and laboratory findings of eosinophilia, the appearance of skin changes raised suspicion of possible CSS. Skin changes resolved and the patient was reffered to rheumatologist.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300022D.pdfChurg-Strauss syndromediagnosisskin diseaseshistological techniques |
| spellingShingle | Dinić Miroslav Ž. Kandolf-Sekulović Lidija Zolotarevski Lidija Zečević Radoš D. Churg-Strauss syndrome: A case report Vojnosanitetski Pregled Churg-Strauss syndrome diagnosis skin diseases histological techniques |
| title | Churg-Strauss syndrome: A case report |
| title_full | Churg-Strauss syndrome: A case report |
| title_fullStr | Churg-Strauss syndrome: A case report |
| title_full_unstemmed | Churg-Strauss syndrome: A case report |
| title_short | Churg-Strauss syndrome: A case report |
| title_sort | churg strauss syndrome a case report |
| topic | Churg-Strauss syndrome diagnosis skin diseases histological techniques |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300022D.pdf |
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