Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial

Objective In this randomised two-period crossover trial, the objective was to compare acute changes in arterial distensibility between high-intensity interval physical exercise (HIIPE) and moderate-intensity continuous physical exercise (MICPE) sessions in subjects with elevated blood pressure (BP)....

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Main Authors: Sara Rodrigues, Renata Gomes Sanches Verardino, Valéria Costa - Hong, Camila Paixao Jordao, Marcel Jose Andrade da Costa, Luiz Bortolotto
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Open Heart
Online Access:https://openheart.bmj.com/content/12/1/e003121.full
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author Sara Rodrigues
Renata Gomes Sanches Verardino
Valéria Costa - Hong
Camila Paixao Jordao
Marcel Jose Andrade da Costa
Luiz Bortolotto
author_facet Sara Rodrigues
Renata Gomes Sanches Verardino
Valéria Costa - Hong
Camila Paixao Jordao
Marcel Jose Andrade da Costa
Luiz Bortolotto
author_sort Sara Rodrigues
collection DOAJ
description Objective In this randomised two-period crossover trial, the objective was to compare acute changes in arterial distensibility between high-intensity interval physical exercise (HIIPE) and moderate-intensity continuous physical exercise (MICPE) sessions in subjects with elevated blood pressure (BP).Methods and analysis Participants underwent either MICPE-HIIPE or HIIPE-MICPE sequences with intensity based on cardiopulmonary exercise testing. The main outcome measures included arterial stiffness (by pulse wave velocity (PWV)) at baseline, until 30 min and 24 hours after each physical exercise session. Other measures include office BP, 24-hour ambulatory blood pressure monitoring (ABPM) and applanation tonometry.Results The study involved 29 subjects with elevated BP (76% female, 48±7 years, body mass index=28.3±4.3 kg/m², systolic BP=126±9 mm Hg and diastolic BP=84±4 mm Hg). They presented lower PWV 24 hours after MICPE compared with baseline and to 24-hour HIIPE ((−0.83 (−1.29;−0.37) p=0.001) and (−0.98 (−1.84;−0.12), p=0.021), respectively). Despite no differences in office BP, aortic systolic BP was lower after HIIPE compared with baseline and to 24-hour MICPE (113±19; 118±10 and 117±10 mm Hg; p=0.013).Conclusion In subjects with elevated BP, arterial distensibility is greater 24 hours after MICPE, while aortic systolic BP is lower after HIIPE. The particularities of each method and each exercise intensity can provide specific mechanisms of vascular response to exercise and detect vascular damage early in these subjects.Trial registration number NCT04200716.
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spelling doaj-art-96e42eab0b594ba28693c5caef1427322025-08-20T03:06:42ZengBMJ Publishing GroupOpen Heart2053-36242025-04-0112110.1136/openhrt-2024-003121Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trialSara Rodrigues0Renata Gomes Sanches Verardino1Valéria Costa - Hong2Camila Paixao Jordao3Marcel Jose Andrade da Costa4Luiz Bortolotto5Unidade de Hipertensão, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, BrazilUnidade de Hipertensão, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, BrazilUnidade de Hipertensão, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, BrazilUniversidade de São Paulo Instituto do Coração, Sao Paulo, BrazilUnidade de Exercício Físico e Reabilitação, Instituto do Coração (InCor), Hospital das Clinicas, HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, BrazilUnidade de Hipertensão, Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, BrazilObjective In this randomised two-period crossover trial, the objective was to compare acute changes in arterial distensibility between high-intensity interval physical exercise (HIIPE) and moderate-intensity continuous physical exercise (MICPE) sessions in subjects with elevated blood pressure (BP).Methods and analysis Participants underwent either MICPE-HIIPE or HIIPE-MICPE sequences with intensity based on cardiopulmonary exercise testing. The main outcome measures included arterial stiffness (by pulse wave velocity (PWV)) at baseline, until 30 min and 24 hours after each physical exercise session. Other measures include office BP, 24-hour ambulatory blood pressure monitoring (ABPM) and applanation tonometry.Results The study involved 29 subjects with elevated BP (76% female, 48±7 years, body mass index=28.3±4.3 kg/m², systolic BP=126±9 mm Hg and diastolic BP=84±4 mm Hg). They presented lower PWV 24 hours after MICPE compared with baseline and to 24-hour HIIPE ((−0.83 (−1.29;−0.37) p=0.001) and (−0.98 (−1.84;−0.12), p=0.021), respectively). Despite no differences in office BP, aortic systolic BP was lower after HIIPE compared with baseline and to 24-hour MICPE (113±19; 118±10 and 117±10 mm Hg; p=0.013).Conclusion In subjects with elevated BP, arterial distensibility is greater 24 hours after MICPE, while aortic systolic BP is lower after HIIPE. The particularities of each method and each exercise intensity can provide specific mechanisms of vascular response to exercise and detect vascular damage early in these subjects.Trial registration number NCT04200716.https://openheart.bmj.com/content/12/1/e003121.full
spellingShingle Sara Rodrigues
Renata Gomes Sanches Verardino
Valéria Costa - Hong
Camila Paixao Jordao
Marcel Jose Andrade da Costa
Luiz Bortolotto
Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
Open Heart
title Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
title_full Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
title_fullStr Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
title_full_unstemmed Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
title_short Evaluation of vascular responses to moderate-intensity continuous and high-intensity interval physical exercise in subjects with elevated blood pressure: a randomised, cross-over clinical trial
title_sort evaluation of vascular responses to moderate intensity continuous and high intensity interval physical exercise in subjects with elevated blood pressure a randomised cross over clinical trial
url https://openheart.bmj.com/content/12/1/e003121.full
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