<i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis
<b>Background/Objectives</b>: Wannachawee recipe (WCR) has been listed in the Hospital Traditional Medicine Formulary and has been used as a Thai medicine to treat psoriasis in the Thai Traditional Medicine Clinic of Prapokklao Hospital since 2006. Previous reports have found that WCR de...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/7/864 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849251875606495232 |
|---|---|
| author | Supreeya Tantipat Kongkiat Trisuwan Phraepakaporn Kunnaja Seewaboon Sireeratawong Surapol Natakankitkul Surasak Imiam Sunee Chansakaow |
| author_facet | Supreeya Tantipat Kongkiat Trisuwan Phraepakaporn Kunnaja Seewaboon Sireeratawong Surapol Natakankitkul Surasak Imiam Sunee Chansakaow |
| author_sort | Supreeya Tantipat |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Wannachawee recipe (WCR) has been listed in the Hospital Traditional Medicine Formulary and has been used as a Thai medicine to treat psoriasis in the Thai Traditional Medicine Clinic of Prapokklao Hospital since 2006. Previous reports have found that WCR demonstrates good results for the treatment of patients with psoriasis. Among 136 Thai psoriasis patients who received WCR, 92.80% responded well. Although WCR is effective, there is still a lack of scientific data, especially relating to the bioactive compound in WCR. Therefore, this study aims to evaluate the phytochemicals in WCR via bioassay-guided isolation. <b>Methods</b>: In this study, the WCR was extracted via decoction with water, in a process based on traditional Thai medicine. The water extract was concentrated and dried using a spray dryer. The crude water extract was isolated using the partition technique with organic solvents, namely petroleum ether and ethyl acetate. These fractions were then separated and tested for anti-inflammatory activity using the bioassay-guided fractionation method. <b>Results</b>: Two particular types of pro-inflammatory cytokines are involved in inflammation and are among the factors that cause psoriasis—TNF-<i>α</i> and IL-6. Thus, we evaluated the isolated samples in terms of anti-inflammatory activity. The isolation resulted in two pure compounds—<i>p</i>-coumaryl aldehyde and <i>trans</i>-<i>p</i>-coumaryl alcohol. In the efficacy test of the isolated compounds, compared to the standard indomethacin at the same concentration of 12.5 ug/mL, <i>trans</i>-<i>p</i>-coumaryl alcohol was found to have the best efficacy, inhibiting TNF-<i>α</i> by 29.28% and IL-6 by 36.75%, with the standard compound showing inhibitions rates of 15.80% for TNF-<i>α</i> and 27.44% for IL-6. <b>Conclusions</b>: This study is the first report to identify the bioactive compound of WCR as <i>trans</i>-<i>p</i>-coumaryl alcohol or 4-hydroxycinnamyl alcohol. |
| format | Article |
| id | doaj-art-96dff13a71ba4afa953df859a83ea33b |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-96dff13a71ba4afa953df859a83ea33b2025-08-20T03:56:47ZengMDPI AGPharmaceutics1999-49232025-06-0117786410.3390/pharmaceutics17070864<i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for PsoriasisSupreeya Tantipat0Kongkiat Trisuwan1Phraepakaporn Kunnaja2Seewaboon Sireeratawong3Surapol Natakankitkul4Surasak Imiam5Sunee Chansakaow6Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Thai Traditional Medicine, Phrapokklao Hospital, Chanthaburi 22000, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand<b>Background/Objectives</b>: Wannachawee recipe (WCR) has been listed in the Hospital Traditional Medicine Formulary and has been used as a Thai medicine to treat psoriasis in the Thai Traditional Medicine Clinic of Prapokklao Hospital since 2006. Previous reports have found that WCR demonstrates good results for the treatment of patients with psoriasis. Among 136 Thai psoriasis patients who received WCR, 92.80% responded well. Although WCR is effective, there is still a lack of scientific data, especially relating to the bioactive compound in WCR. Therefore, this study aims to evaluate the phytochemicals in WCR via bioassay-guided isolation. <b>Methods</b>: In this study, the WCR was extracted via decoction with water, in a process based on traditional Thai medicine. The water extract was concentrated and dried using a spray dryer. The crude water extract was isolated using the partition technique with organic solvents, namely petroleum ether and ethyl acetate. These fractions were then separated and tested for anti-inflammatory activity using the bioassay-guided fractionation method. <b>Results</b>: Two particular types of pro-inflammatory cytokines are involved in inflammation and are among the factors that cause psoriasis—TNF-<i>α</i> and IL-6. Thus, we evaluated the isolated samples in terms of anti-inflammatory activity. The isolation resulted in two pure compounds—<i>p</i>-coumaryl aldehyde and <i>trans</i>-<i>p</i>-coumaryl alcohol. In the efficacy test of the isolated compounds, compared to the standard indomethacin at the same concentration of 12.5 ug/mL, <i>trans</i>-<i>p</i>-coumaryl alcohol was found to have the best efficacy, inhibiting TNF-<i>α</i> by 29.28% and IL-6 by 36.75%, with the standard compound showing inhibitions rates of 15.80% for TNF-<i>α</i> and 27.44% for IL-6. <b>Conclusions</b>: This study is the first report to identify the bioactive compound of WCR as <i>trans</i>-<i>p</i>-coumaryl alcohol or 4-hydroxycinnamyl alcohol.https://www.mdpi.com/1999-4923/17/7/864Wannachawee recipepsoriasisanti-inflammatory activity<i>p</i>-coumaryl aldehyde<i>trans</i>-<i>p</i>-coumaryl alcohol |
| spellingShingle | Supreeya Tantipat Kongkiat Trisuwan Phraepakaporn Kunnaja Seewaboon Sireeratawong Surapol Natakankitkul Surasak Imiam Sunee Chansakaow <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis Pharmaceutics Wannachawee recipe psoriasis anti-inflammatory activity <i>p</i>-coumaryl aldehyde <i>trans</i>-<i>p</i>-coumaryl alcohol |
| title | <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis |
| title_full | <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis |
| title_fullStr | <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis |
| title_full_unstemmed | <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis |
| title_short | <i>Trans</i>-<i>p</i>-Coumaryl Alcohol as a Bioactive Compound and Anti-Inflammatory Agent in Wannachawee Recipe for Psoriasis |
| title_sort | i trans i i p i coumaryl alcohol as a bioactive compound and anti inflammatory agent in wannachawee recipe for psoriasis |
| topic | Wannachawee recipe psoriasis anti-inflammatory activity <i>p</i>-coumaryl aldehyde <i>trans</i>-<i>p</i>-coumaryl alcohol |
| url | https://www.mdpi.com/1999-4923/17/7/864 |
| work_keys_str_mv | AT supreeyatantipat itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT kongkiattrisuwan itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT phraepakapornkunnaja itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT seewaboonsireeratawong itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT surapolnatakankitkul itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT surasakimiam itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis AT suneechansakaow itransiipicoumarylalcoholasabioactivecompoundandantiinflammatoryagentinwannachaweerecipeforpsoriasis |