Increased serum uric acid to creatinine ratio is associated with metabolic dysfunction associated steatotic liver disease
Abstract To investigate the correlation between the serum uric acid to creatinine ratio (SUA/SCr) and the severity of hepatic steatosis in individuals with MASLD. A total of 34,981 individuals were measured the controlled attenuated parameter (CAP) using transient elastography (TE), then we studied...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09073-0 |
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| Summary: | Abstract To investigate the correlation between the serum uric acid to creatinine ratio (SUA/SCr) and the severity of hepatic steatosis in individuals with MASLD. A total of 34,981 individuals were measured the controlled attenuated parameter (CAP) using transient elastography (TE), then we studied the association between SUA/SCr and the severity of hepatic steatosis defined with the value of CAP. A cohort of 2179 individuals without MASLD were followed up to investigate the relationship between SUA/SCr and the incidence of MASLD during the following 33 months. After adjusting for confounding factors, smooth fitting curve and threshold saturation analysis showed that SUA/SCr exhibited a significant positive correlation with CAP (P < 0.0001), with different inflection points in sex, BMI and age subgroups. Logistic regression analysis showed that SUA/SCr demonstrated a certain degree of predictive value for MASLD (P < 0.001). In followed-up population, individuals with higher SUA/SCr exhibited a significantly increased cumulative incidence of MASLD (P = 0.0008). Increased SUA/SCr levels are associated with the severity of hepatic steatosis in MASLD, is an independent risk factor for MASLD. Individuals with elevated levels of SUA/SCr are at a higher risk of developing MASLD. Maybe SUA/SCr could be considered as a useful biomarker for MASLD in clinical work, although the predictive value is limited, and further validation and combined usage with other markers are necessary. |
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| ISSN: | 2045-2322 |