TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells

TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells

Abstract Critical-sized bone defects, characterized by poor spontaneous healing capacity, remain a common clinical challenge, and stem cell and gene therapies are key strategies for bone repair and regeneration. Transcription factor 7-like 2 (TCF7L2) is a key regulator of the Wnt signaling pathway,...

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Bibliographic Details
Main Authors: Ming Lei, Boyu Liu, Baicheng Wan, Yanbin Feng, Yilin Teng, Deshuang Xi, Gaofeng Zeng, Shaohui Zong
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Subjects:
TCF7L2
GPX4
Osteogenesis
Ferroptosis
Osteogenic differentiation
BMSCs
Online Access:https://doi.org/10.1186/s40001-025-02993-7
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