Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this diseas...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/8749291 |
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| author | Guangtong Dong Lianlian Qu Xuefeng Gong Bing Pang Weitian Yan Junping Wei |
| author_facet | Guangtong Dong Lianlian Qu Xuefeng Gong Bing Pang Weitian Yan Junping Wei |
| author_sort | Guangtong Dong |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through nonenvironmental and behavioral interventions. |
| format | Article |
| id | doaj-art-96decdd49a844e0ebe33f073708b4a25 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-96decdd49a844e0ebe33f073708b4a252025-02-03T01:00:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/87492918749291Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes MellitusGuangtong Dong0Lianlian Qu1Xuefeng Gong2Bing Pang3Weitian Yan4Junping Wei5Guang’anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, ChinaPenglai Traditional Chinese Hospital, Shandong, ChinaThe Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, ChinaType 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through nonenvironmental and behavioral interventions.http://dx.doi.org/10.1155/2019/8749291 |
| spellingShingle | Guangtong Dong Lianlian Qu Xuefeng Gong Bing Pang Weitian Yan Junping Wei Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus International Journal of Endocrinology |
| title | Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus |
| title_full | Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus |
| title_fullStr | Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus |
| title_full_unstemmed | Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus |
| title_short | Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus |
| title_sort | effect of social factors and the natural environment on the etiology and pathogenesis of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2019/8749291 |
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