Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy
The modern pathogenesis of the neurodegenerative process in glaucoma identifies several key risk factors for its development: ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation. An analysis of recent studies shows that in glaucomatous optic neuropathy, as in other ne...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2024-12-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/1636 |
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| author | T. A. Pavlenko S. Yu. Petrov E. N. Iomdina |
| author_facet | T. A. Pavlenko S. Yu. Petrov E. N. Iomdina |
| author_sort | T. A. Pavlenko |
| collection | DOAJ |
| description | The modern pathogenesis of the neurodegenerative process in glaucoma identifies several key risk factors for its development: ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation. An analysis of recent studies shows that in glaucomatous optic neuropathy, as in other neurodegenerative diseases, the immune system is involved in the pathological process, and immunoregulation is carried out mainly by retinal glial cells, microglia, astrocytes, Müller cells and the complement system. Chronic activation of glial cells caused by increased intraocular pressure in glaucoma can provoke a pro-inflammatory state at the retinal level, causing disruption of the blood-retinal barrier and death of retinal ganglion cells. The review presents pro-inflammatory markers of glaucoma, immunomodulatory and pro-inflammatory mediators, shows the role of a number of metalloproteinases and their tissue inhibitors, as well as pro-inflammatory cytokines in the development of glaucoma. |
| format | Article |
| id | doaj-art-96d91df4f2ee4c529050f3b7bbbe4411 |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-96d91df4f2ee4c529050f3b7bbbe44112025-08-20T03:40:10ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602024-12-0117413514010.21516/2072-0076-2024-17-4-135-140750Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathyT. A. Pavlenko0S. Yu. Petrov1E. N. Iomdina2Helmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesThe modern pathogenesis of the neurodegenerative process in glaucoma identifies several key risk factors for its development: ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation. An analysis of recent studies shows that in glaucomatous optic neuropathy, as in other neurodegenerative diseases, the immune system is involved in the pathological process, and immunoregulation is carried out mainly by retinal glial cells, microglia, astrocytes, Müller cells and the complement system. Chronic activation of glial cells caused by increased intraocular pressure in glaucoma can provoke a pro-inflammatory state at the retinal level, causing disruption of the blood-retinal barrier and death of retinal ganglion cells. The review presents pro-inflammatory markers of glaucoma, immunomodulatory and pro-inflammatory mediators, shows the role of a number of metalloproteinases and their tissue inhibitors, as well as pro-inflammatory cytokines in the development of glaucoma.https://roj.igb.ru/jour/article/view/1636glaucomaoptic neuropathyoxidative stressimmunoregulationretinal glial cellspro-inflammatory markers |
| spellingShingle | T. A. Pavlenko S. Yu. Petrov E. N. Iomdina Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy Российский офтальмологический журнал glaucoma optic neuropathy oxidative stress immunoregulation retinal glial cells pro-inflammatory markers |
| title | Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| title_full | Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| title_fullStr | Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| title_full_unstemmed | Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| title_short | Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| title_sort | neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy |
| topic | glaucoma optic neuropathy oxidative stress immunoregulation retinal glial cells pro-inflammatory markers |
| url | https://roj.igb.ru/jour/article/view/1636 |
| work_keys_str_mv | AT tapavlenko neuroinflammationasafactorofpathogenesisofglaucomatousopticneuropathy AT syupetrov neuroinflammationasafactorofpathogenesisofglaucomatousopticneuropathy AT eniomdina neuroinflammationasafactorofpathogenesisofglaucomatousopticneuropathy |