Recent advances in mitochondrial turnover during chronic muscle disuse
Chronic muscle disuse, such as that resulting from immobilization, denervation, or prolonged physical inactivity, produces atrophy and a loss of mitochondria, yet the molecular relationship between these events is not fully understood. In this review we attempt to identify the key regulatory steps m...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221342201400064X |
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| _version_ | 1850199101695590400 |
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| author | Liam D. Tryon Anna Vainshtein Jonathan M. Memme Matthew J. Crilly David A. Hood |
| author_facet | Liam D. Tryon Anna Vainshtein Jonathan M. Memme Matthew J. Crilly David A. Hood |
| author_sort | Liam D. Tryon |
| collection | DOAJ |
| description | Chronic muscle disuse, such as that resulting from immobilization, denervation, or prolonged physical inactivity, produces atrophy and a loss of mitochondria, yet the molecular relationship between these events is not fully understood. In this review we attempt to identify the key regulatory steps mediating the loss of muscle mass and the decline in mitochondrial content and function. An understanding of common intracellular signaling pathways may provide much-needed insight into the possible therapeutic targets for treatments that will maintain aerobic energy metabolism and preserve muscle mass during disuse conditions. |
| format | Article |
| id | doaj-art-96d7b7724937460baaa1a6b330feb712 |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-96d7b7724937460baaa1a6b330feb7122025-08-20T02:12:42ZengElsevierIntegrative Medicine Research2213-42202014-12-013416117110.1016/j.imr.2014.09.001Recent advances in mitochondrial turnover during chronic muscle disuseLiam D. TryonAnna VainshteinJonathan M. MemmeMatthew J. CrillyDavid A. HoodChronic muscle disuse, such as that resulting from immobilization, denervation, or prolonged physical inactivity, produces atrophy and a loss of mitochondria, yet the molecular relationship between these events is not fully understood. In this review we attempt to identify the key regulatory steps mediating the loss of muscle mass and the decline in mitochondrial content and function. An understanding of common intracellular signaling pathways may provide much-needed insight into the possible therapeutic targets for treatments that will maintain aerobic energy metabolism and preserve muscle mass during disuse conditions.http://www.sciencedirect.com/science/article/pii/S221342201400064Xdenervationmitochondrial biogenesismitophagyprotein degradationskeletal muscle |
| spellingShingle | Liam D. Tryon Anna Vainshtein Jonathan M. Memme Matthew J. Crilly David A. Hood Recent advances in mitochondrial turnover during chronic muscle disuse Integrative Medicine Research denervation mitochondrial biogenesis mitophagy protein degradation skeletal muscle |
| title | Recent advances in mitochondrial turnover during chronic muscle disuse |
| title_full | Recent advances in mitochondrial turnover during chronic muscle disuse |
| title_fullStr | Recent advances in mitochondrial turnover during chronic muscle disuse |
| title_full_unstemmed | Recent advances in mitochondrial turnover during chronic muscle disuse |
| title_short | Recent advances in mitochondrial turnover during chronic muscle disuse |
| title_sort | recent advances in mitochondrial turnover during chronic muscle disuse |
| topic | denervation mitochondrial biogenesis mitophagy protein degradation skeletal muscle |
| url | http://www.sciencedirect.com/science/article/pii/S221342201400064X |
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