Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells

Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells

Abnormal elevations in the mortality of intestinal epithelial cells (IECs) are indicative of intestinal inflammation. Necroptosis of IECs represents a pro-inflammatory form of cell death, and modulation of IECs necroptosis may mitigate subsequent intestinal inflammation and preserve the integrity of...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Siqi Liu, Keyi Lu, Erping Xu, Zhibin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Gambogic acid
ulcerative colitis
necroptosis
Hsp90
IECs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586705/full
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