Malformations of cortical development and epilepsy: evaluation of 101 cases (part II)
Malformations of cortical development (MCD) form a spectrum of lesions produced by insult to the developing neocortex. Clinical presentation and electrophysiologic findings of MCD are variable and depend on the affected cortical area. We evaluated epilepsy, EEG, and response to antiepileptic...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2007-04-01
|
| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2525 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850236530126225408 |
|---|---|
| author | Serdal Güngör Dilek Yalnizoğlu Güzide Turanli Işil Saatçi Emel Erdoğan-Bakar Meral Topçu |
| author_facet | Serdal Güngör Dilek Yalnizoğlu Güzide Turanli Işil Saatçi Emel Erdoğan-Bakar Meral Topçu |
| author_sort | Serdal Güngör |
| collection | DOAJ |
| description |
Malformations of cortical development (MCD) form a spectrum of lesions produced by insult to the developing neocortex. Clinical presentation and electrophysiologic findings of MCD are variable and depend on the affected cortical area. We evaluated epilepsy, EEG, and response to antiepileptic treatment in patients with MCD with respect to the neuroimaging findings. We studied 101 patients, ranging between 1 month and 19 years of age. Fifty-four patients were diagnosed with polymicrogyria (PMG), 23 patients with lissencephaly, 12 patients with schizencephaly, and 12 patients with heterotopia. With regards to epilepsy and seizure type, 72/101 (71.3%) patients had epilepsy, and 62/101 (61.4%) patients presented with seizures. Overall, 32.7% of patients had generalized seizures, and 25.7% had complex partial seizures. Mean age at the onset of seizures was 2.7 +/- 3.4 years. The onset of epilepsy tended to be younger in patients with lissencephaly and older in patients with heterotopias. Of the cases, 79.2% had abnormal EEG (56.3% with epileptiform abnormality, 22.9% with non-epileptiform abnormality). EEG was abnormal in 44.9% (13/29) of the cases without epilepsy. EEG showed bilateral synchronous and diffuse epileptiform discharges in 90% of patients with lissencephaly. Patients with schizencephaly had mostly focal epileptiform discharges. Heterotopia cases had a high rate of EEG abnormalities (72.7%). Patients with PMG had epileptiform abnormality in 59.5% of the cases. Patients with heterotopias and PMG achieved better seizure control in comparison with the other groups. In conclusion, epilepsy is the most common problem in MCD. Epilepsy and EEG findings of patients with MCD are variable and seem to be correlated with the extent of cortical involvement.
|
| format | Article |
| id | doaj-art-96d355290af04eaeafe10135dcdc52c9 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-96d355290af04eaeafe10135dcdc52c92025-08-20T02:01:57ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212007-04-01492Malformations of cortical development and epilepsy: evaluation of 101 cases (part II)Serdal Güngör0Dilek YalnizoğluGüzide TuranliIşil SaatçiEmel Erdoğan-BakarMeral TopçuDepartment of Pediatrics, Inönü University, Faculty of Medicine, Malatya, Turkey. Malformations of cortical development (MCD) form a spectrum of lesions produced by insult to the developing neocortex. Clinical presentation and electrophysiologic findings of MCD are variable and depend on the affected cortical area. We evaluated epilepsy, EEG, and response to antiepileptic treatment in patients with MCD with respect to the neuroimaging findings. We studied 101 patients, ranging between 1 month and 19 years of age. Fifty-four patients were diagnosed with polymicrogyria (PMG), 23 patients with lissencephaly, 12 patients with schizencephaly, and 12 patients with heterotopia. With regards to epilepsy and seizure type, 72/101 (71.3%) patients had epilepsy, and 62/101 (61.4%) patients presented with seizures. Overall, 32.7% of patients had generalized seizures, and 25.7% had complex partial seizures. Mean age at the onset of seizures was 2.7 +/- 3.4 years. The onset of epilepsy tended to be younger in patients with lissencephaly and older in patients with heterotopias. Of the cases, 79.2% had abnormal EEG (56.3% with epileptiform abnormality, 22.9% with non-epileptiform abnormality). EEG was abnormal in 44.9% (13/29) of the cases without epilepsy. EEG showed bilateral synchronous and diffuse epileptiform discharges in 90% of patients with lissencephaly. Patients with schizencephaly had mostly focal epileptiform discharges. Heterotopia cases had a high rate of EEG abnormalities (72.7%). Patients with PMG had epileptiform abnormality in 59.5% of the cases. Patients with heterotopias and PMG achieved better seizure control in comparison with the other groups. In conclusion, epilepsy is the most common problem in MCD. Epilepsy and EEG findings of patients with MCD are variable and seem to be correlated with the extent of cortical involvement. https://turkjpediatr.org/article/view/2525 |
| spellingShingle | Serdal Güngör Dilek Yalnizoğlu Güzide Turanli Işil Saatçi Emel Erdoğan-Bakar Meral Topçu Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) The Turkish Journal of Pediatrics |
| title | Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) |
| title_full | Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) |
| title_fullStr | Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) |
| title_full_unstemmed | Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) |
| title_short | Malformations of cortical development and epilepsy: evaluation of 101 cases (part II) |
| title_sort | malformations of cortical development and epilepsy evaluation of 101 cases part ii |
| url | https://turkjpediatr.org/article/view/2525 |
| work_keys_str_mv | AT serdalgungor malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii AT dilekyalnizoglu malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii AT guzideturanli malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii AT isilsaatci malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii AT emelerdoganbakar malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii AT meraltopcu malformationsofcorticaldevelopmentandepilepsyevaluationof101casespartii |