Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
<h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to su...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0089223 |
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| author | Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou |
| author_facet | Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou |
| author_sort | Jian Wang |
| collection | DOAJ |
| description | <h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.<h4>Methodology/principal findings</h4>The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).<h4>Conclusions/significance</h4>This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant. |
| format | Article |
| id | doaj-art-96cf0e82264e4b4aa2207934c54dff5a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-96cf0e82264e4b4aa2207934c54dff5a2025-08-20T03:34:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8922310.1371/journal.pone.0089223Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.Jian WangJiqing ZhaoMengjing ShiYu DingHuiqin SunFahuan YuanZhongmin Zou<h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.<h4>Methodology/principal findings</h4>The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).<h4>Conclusions/significance</h4>This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.https://doi.org/10.1371/journal.pone.0089223 |
| spellingShingle | Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. PLoS ONE |
| title | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. |
| title_full | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. |
| title_fullStr | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. |
| title_full_unstemmed | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. |
| title_short | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. |
| title_sort | elevated expression of mir 210 predicts poor survival of cancer patients a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0089223 |
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