Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms
Dachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects. A large number of studies have shown that DCQD has a significant impact on the...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1549909/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849716976153264128 |
|---|---|
| author | Wen Guo Wen Guo Xiaobin Zhang Xiaobin Zhang Xin Zhou Xin Zhou Wangpeng Lan Wangpeng Lan Jianqin Liu Yali Liu Yali Liu Li Li Li Li Zhi Li Zhi Li Zhi Li |
| author_facet | Wen Guo Wen Guo Xiaobin Zhang Xiaobin Zhang Xin Zhou Xin Zhou Wangpeng Lan Wangpeng Lan Jianqin Liu Yali Liu Yali Liu Li Li Li Li Zhi Li Zhi Li Zhi Li |
| author_sort | Wen Guo |
| collection | DOAJ |
| description | Dachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects. A large number of studies have shown that DCQD has a significant impact on the treatment of acute pancreatitis (AP). However, owing to the multi-component and multi-target characteristics of traditional Chinese medicine, it is difficult for modern scientists to understand the role of DCQD in treating AP. Therefore, We sorted out the literature data related to DCQD published in databases such as Web of Science, PubMed, and CNKI, and summarized the main metabolites of DCQD, including anthraquinones, flavonoids, lignans and other metabolites. The pharmacokinetic characteristics of the main metabolites entering the blood circulation are preliminarily summarized. Combining chemical analysis and network analysis, some metabolites in DCQD, such as emodin, rhein, and luteolin, may play important roles in the treatment of AP, and this review also summarizes the efficacy mechanisms of these metabolites. In brief, we have summarized the treatment of AP with DCQD from the aspects of metabolites, preliminary pharmacokinetic analysis, and efficacy mechanisms, to facilitate further understanding of the material basis of DCQD. |
| format | Article |
| id | doaj-art-96ce7e4ed44b47c0aa065f96fcd9d7e1 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-96ce7e4ed44b47c0aa065f96fcd9d7e12025-08-20T03:12:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15499091549909Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanismsWen Guo0Wen Guo1Xiaobin Zhang2Xiaobin Zhang3Xin Zhou4Xin Zhou5Wangpeng Lan6Wangpeng Lan7Jianqin Liu8Yali Liu9Yali Liu10Li Li11Li Li12Zhi Li13Zhi Li14Zhi Li15Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaResearch Center of Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, ChinaSchool of Integrated Traditional Chinese and Western Clinical Medicine, North Sichuan Medical College, Nanchong, ChinaDachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects. A large number of studies have shown that DCQD has a significant impact on the treatment of acute pancreatitis (AP). However, owing to the multi-component and multi-target characteristics of traditional Chinese medicine, it is difficult for modern scientists to understand the role of DCQD in treating AP. Therefore, We sorted out the literature data related to DCQD published in databases such as Web of Science, PubMed, and CNKI, and summarized the main metabolites of DCQD, including anthraquinones, flavonoids, lignans and other metabolites. The pharmacokinetic characteristics of the main metabolites entering the blood circulation are preliminarily summarized. Combining chemical analysis and network analysis, some metabolites in DCQD, such as emodin, rhein, and luteolin, may play important roles in the treatment of AP, and this review also summarizes the efficacy mechanisms of these metabolites. In brief, we have summarized the treatment of AP with DCQD from the aspects of metabolites, preliminary pharmacokinetic analysis, and efficacy mechanisms, to facilitate further understanding of the material basis of DCQD.https://www.frontiersin.org/articles/10.3389/fphar.2025.1549909/fullDaChengQi decoctionacute pancreatitistraditional Chinese medicinemetaboliteefficacy mechanisms |
| spellingShingle | Wen Guo Wen Guo Xiaobin Zhang Xiaobin Zhang Xin Zhou Xin Zhou Wangpeng Lan Wangpeng Lan Jianqin Liu Yali Liu Yali Liu Li Li Li Li Zhi Li Zhi Li Zhi Li Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms Frontiers in Pharmacology DaChengQi decoction acute pancreatitis traditional Chinese medicine metabolite efficacy mechanisms |
| title | Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms |
| title_full | Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms |
| title_fullStr | Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms |
| title_full_unstemmed | Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms |
| title_short | Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms |
| title_sort | dachengqi decoction for the treatment of acute pancreatitis a comprehensive analysis based on metabolites pharmacokinetics and metabolites efficacy mechanisms |
| topic | DaChengQi decoction acute pancreatitis traditional Chinese medicine metabolite efficacy mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1549909/full |
| work_keys_str_mv | AT wenguo dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT wenguo dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT xiaobinzhang dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT xiaobinzhang dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT xinzhou dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT xinzhou dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT wangpenglan dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT wangpenglan dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT jianqinliu dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT yaliliu dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT yaliliu dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT lili dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT lili dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT zhili dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT zhili dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms AT zhili dachengqidecoctionforthetreatmentofacutepancreatitisacomprehensiveanalysisbasedonmetabolitespharmacokineticsandmetabolitesefficacymechanisms |