Cutaneous Sarcoidosis – Diagnostic Challenges
Sarcoidosis is a multisystemic granulomatous disease, with unknown etiology, characterized histopathologically by the development in the affected organs of some „empty” (non-caseous) granulomas. Cutaneous lesions can sometimes be the first localization of the disease. We present the case of a patie...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bucharest College of Physicians
2019-12-01
|
| Series: | Modern Medicine |
| Subjects: | |
| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2019/12/RMM_art-11-Cutaneous-Sarcoidosis-%E2%80%93-Diagnostic-Challenges.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850145128294907904 |
|---|---|
| author | Florica SANDRU Mihai Cristian DUMITRASCU Adelina POPA Daniel-Vasile BALABAN Razvan-Cosmin PETCA Raluca Gabriela MIULESCU |
| author_facet | Florica SANDRU Mihai Cristian DUMITRASCU Adelina POPA Daniel-Vasile BALABAN Razvan-Cosmin PETCA Raluca Gabriela MIULESCU |
| author_sort | Florica SANDRU |
| collection | DOAJ |
| description | Sarcoidosis is a multisystemic granulomatous disease, with unknown etiology, characterized histopathologically
by the development in the affected organs of some „empty” (non-caseous) granulomas. Cutaneous lesions can sometimes be the first localization of the disease. We present the case of a patient with known sarcoidosis and
autoimmune thyroiditis, who developed a rash spread on the trunk and limbs, for which she was treated with dermatocorticoids and antihistamines, but without significant improvement. A skin biopsy was performed with histopathological examination, which revealed: at the dermal level, lympho-histiocytic infiltrates with nodular distribution, forming several granulomas, without areas of necrosis of caseification, including frequent cells with epithelioid appearance, suggestive for the diagnosis of cutaneous sarcoidosis. The patient underwent systemic cortisone therapy and hydroxychloroquine, with favorable outcome. The challenge of diagnosing this pathology is to differentiate it from a number of conditions, including: ring granuloma, cutaneous Crohn’s disease, lipoid necrosis, lupus vulgaris. To establish the diagnosis of certainty, it is necessary to correlate the clinical data with the result of the histopathological examination. |
| format | Article |
| id | doaj-art-96cbb7ad2e284cfabc5ca81a819374a4 |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-96cbb7ad2e284cfabc5ca81a819374a42025-08-20T02:28:10ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732019-12-01264233237https://doi.org/10.31689/rmm.2019.26.4.233Cutaneous Sarcoidosis – Diagnostic ChallengesFlorica SANDRU0Mihai Cristian DUMITRASCU1Adelina POPA2Daniel-Vasile BALABAN3Razvan-Cosmin PETCA4Raluca Gabriela MIULESCU5Department of Dermatology, „Elias” Emergency University Hospital, Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, RomaniaDepartment of Dermatology, „Elias” Emergency University Hospital, Bucharest, RomaniaDepartment of Gastroenterology, „Dr. Carol Davila” Central Military Emergency University Hospital, Bucharest, RomaniaDepartment of Urology, „Prof. Dr. Th. Burghele” Clinical Hospital, Bucharest, RomaniaDepartment of Dermatology, „Elias” Emergency University Hospital, Bucharest, RomaniaSarcoidosis is a multisystemic granulomatous disease, with unknown etiology, characterized histopathologically by the development in the affected organs of some „empty” (non-caseous) granulomas. Cutaneous lesions can sometimes be the first localization of the disease. We present the case of a patient with known sarcoidosis and autoimmune thyroiditis, who developed a rash spread on the trunk and limbs, for which she was treated with dermatocorticoids and antihistamines, but without significant improvement. A skin biopsy was performed with histopathological examination, which revealed: at the dermal level, lympho-histiocytic infiltrates with nodular distribution, forming several granulomas, without areas of necrosis of caseification, including frequent cells with epithelioid appearance, suggestive for the diagnosis of cutaneous sarcoidosis. The patient underwent systemic cortisone therapy and hydroxychloroquine, with favorable outcome. The challenge of diagnosing this pathology is to differentiate it from a number of conditions, including: ring granuloma, cutaneous Crohn’s disease, lipoid necrosis, lupus vulgaris. To establish the diagnosis of certainty, it is necessary to correlate the clinical data with the result of the histopathological examination.https://medicinamoderna.ro/wp-content/uploads/2019/12/RMM_art-11-Cutaneous-Sarcoidosis-%E2%80%93-Diagnostic-Challenges.pdfsarcoidosisgranulomatous diseaselichen planuscutaneous crohn’s diseaselipoid necrobiosisclassic ring granuloma |
| spellingShingle | Florica SANDRU Mihai Cristian DUMITRASCU Adelina POPA Daniel-Vasile BALABAN Razvan-Cosmin PETCA Raluca Gabriela MIULESCU Cutaneous Sarcoidosis – Diagnostic Challenges Modern Medicine sarcoidosis granulomatous disease lichen planus cutaneous crohn’s disease lipoid necrobiosis classic ring granuloma |
| title | Cutaneous Sarcoidosis – Diagnostic Challenges |
| title_full | Cutaneous Sarcoidosis – Diagnostic Challenges |
| title_fullStr | Cutaneous Sarcoidosis – Diagnostic Challenges |
| title_full_unstemmed | Cutaneous Sarcoidosis – Diagnostic Challenges |
| title_short | Cutaneous Sarcoidosis – Diagnostic Challenges |
| title_sort | cutaneous sarcoidosis diagnostic challenges |
| topic | sarcoidosis granulomatous disease lichen planus cutaneous crohn’s disease lipoid necrobiosis classic ring granuloma |
| url | https://medicinamoderna.ro/wp-content/uploads/2019/12/RMM_art-11-Cutaneous-Sarcoidosis-%E2%80%93-Diagnostic-Challenges.pdf |
| work_keys_str_mv | AT floricasandru cutaneoussarcoidosisdiagnosticchallenges AT mihaicristiandumitrascu cutaneoussarcoidosisdiagnosticchallenges AT adelinapopa cutaneoussarcoidosisdiagnosticchallenges AT danielvasilebalaban cutaneoussarcoidosisdiagnosticchallenges AT razvancosminpetca cutaneoussarcoidosisdiagnosticchallenges AT ralucagabrielamiulescu cutaneoussarcoidosisdiagnosticchallenges |