Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors
Introduction. Angiotensin-converting enzyme inhibitors are leading cause of drug-induced angioedema, with incidence of 0.1 to 0.2%. The angioedema is not of immune nature; in predisposed individuals it is caused by accumulation of vasoactive mediators due to reduced activity of angiotensinconvert...
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| Format: | Article |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2011-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501104372J.pdf |
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| _version_ | 1849402726245466112 |
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| author | Janković Slobodan M. Stefanović Srđan M. |
| author_facet | Janković Slobodan M. Stefanović Srđan M. |
| author_sort | Janković Slobodan M. |
| collection | DOAJ |
| description | Introduction. Angiotensin-converting enzyme inhibitors are leading cause of drug-induced angioedema, with incidence of 0.1 to 0.2%. The angioedema is not of immune nature; in predisposed individuals it is caused by accumulation of vasoactive mediators due to reduced activity of angiotensinconverting enzyme. Case report. We presented a 63-year old male patient suffering from hypertension and chronic obstructive pulmonary disease, who had developed two episodes of angioedema during a 5-year long therapy with enalapril. The first episode happened after three, and the second after five years of the therapy. On both occasions, the patient was admitted to the hospital and tracheotomy was avoided in the last moment. Conclusion. Long-term therapy with angiotensin-converting enzyme inhibitors could be associated with delayed angioedema, especially in patients with inflammation of airways caused by infection or chronic irritation. |
| format | Article |
| id | doaj-art-96c83df1141d4ada8d552d182bdef289 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-96c83df1141d4ada8d552d182bdef2892025-08-20T03:37:28ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502011-01-0168437237610.2298/VSP1104372JDelayed angioedema during therapy with angiotensin-converting enzyme inhibitorsJanković Slobodan M.Stefanović Srđan M.Introduction. Angiotensin-converting enzyme inhibitors are leading cause of drug-induced angioedema, with incidence of 0.1 to 0.2%. The angioedema is not of immune nature; in predisposed individuals it is caused by accumulation of vasoactive mediators due to reduced activity of angiotensinconverting enzyme. Case report. We presented a 63-year old male patient suffering from hypertension and chronic obstructive pulmonary disease, who had developed two episodes of angioedema during a 5-year long therapy with enalapril. The first episode happened after three, and the second after five years of the therapy. On both occasions, the patient was admitted to the hospital and tracheotomy was avoided in the last moment. Conclusion. Long-term therapy with angiotensin-converting enzyme inhibitors could be associated with delayed angioedema, especially in patients with inflammation of airways caused by infection or chronic irritation.http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501104372J.pdfangiotensin-converting enzyme inhibitorsangioedemaadverse drug reaction reporting systems |
| spellingShingle | Janković Slobodan M. Stefanović Srđan M. Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors Vojnosanitetski Pregled angiotensin-converting enzyme inhibitors angioedema adverse drug reaction reporting systems |
| title | Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors |
| title_full | Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors |
| title_fullStr | Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors |
| title_full_unstemmed | Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors |
| title_short | Delayed angioedema during therapy with angiotensin-converting enzyme inhibitors |
| title_sort | delayed angioedema during therapy with angiotensin converting enzyme inhibitors |
| topic | angiotensin-converting enzyme inhibitors angioedema adverse drug reaction reporting systems |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501104372J.pdf |
| work_keys_str_mv | AT jankovicslobodanm delayedangioedemaduringtherapywithangiotensinconvertingenzymeinhibitors AT stefanovicsrđanm delayedangioedemaduringtherapywithangiotensinconvertingenzymeinhibitors |