The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health
Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly recognized as a significant contributor to ischemic stroke and other cardiovascular diseases due to its association with somatic mutations in hematopoietic cells. These mutations, notably in genes like <i>DNMT3A</i>,...
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MDPI AG
2025-01-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/17/2/19 |
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| author | Aiman Kinzhebay Amankeldi A. Salybekov |
| author_facet | Aiman Kinzhebay Amankeldi A. Salybekov |
| author_sort | Aiman Kinzhebay |
| collection | DOAJ |
| description | Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly recognized as a significant contributor to ischemic stroke and other cardiovascular diseases due to its association with somatic mutations in hematopoietic cells. These mutations, notably in genes like <i>DNMT3A</i>, <i>TET2</i>, and <i>JAK2</i>, induce pro-inflammatory and pro-atherosclerotic processes, promoting vascular damage and stroke risk. With the prevalence of CHIP rising with age, its presence correlates with higher mortality and morbidity rates in ischemic stroke patients. This article explores the mechanisms through which CHIP influences vascular aging and stroke, emphasizing its potential as a biomarker for early risk stratification and a target for therapeutic intervention. The findings highlight the necessity of integrating CHIP status in clinical evaluations to better predict outcomes and personalize treatment strategies in stroke management. |
| format | Article |
| id | doaj-art-96c1e010341c426db1272f6487c4c8e9 |
| institution | DOAJ |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-96c1e010341c426db1272f6487c4c8e92025-08-20T02:44:56ZengMDPI AGNeurology International2035-83772025-01-011721910.3390/neurolint17020019The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular HealthAiman Kinzhebay0Amankeldi A. Salybekov1Qazaq Institute of Innovative Medicine, Regenerative Medicine Division, Cell and Gene Therapy Department, Astana 010000, KazakhstanQazaq Institute of Innovative Medicine, Regenerative Medicine Division, Cell and Gene Therapy Department, Astana 010000, KazakhstanClonal hematopoiesis of indeterminate potential (CHIP) is increasingly recognized as a significant contributor to ischemic stroke and other cardiovascular diseases due to its association with somatic mutations in hematopoietic cells. These mutations, notably in genes like <i>DNMT3A</i>, <i>TET2</i>, and <i>JAK2</i>, induce pro-inflammatory and pro-atherosclerotic processes, promoting vascular damage and stroke risk. With the prevalence of CHIP rising with age, its presence correlates with higher mortality and morbidity rates in ischemic stroke patients. This article explores the mechanisms through which CHIP influences vascular aging and stroke, emphasizing its potential as a biomarker for early risk stratification and a target for therapeutic intervention. The findings highlight the necessity of integrating CHIP status in clinical evaluations to better predict outcomes and personalize treatment strategies in stroke management.https://www.mdpi.com/2035-8377/17/2/19strokeCHIPsomatic mutationvascular dysfunctionischemic strokeatherosclerosis |
| spellingShingle | Aiman Kinzhebay Amankeldi A. Salybekov The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health Neurology International stroke CHIP somatic mutation vascular dysfunction ischemic stroke atherosclerosis |
| title | The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health |
| title_full | The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health |
| title_fullStr | The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health |
| title_full_unstemmed | The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health |
| title_short | The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health |
| title_sort | role of somatic mutations in ischemic stroke chip s impact on vascular health |
| topic | stroke CHIP somatic mutation vascular dysfunction ischemic stroke atherosclerosis |
| url | https://www.mdpi.com/2035-8377/17/2/19 |
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