SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hy...
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
1993-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31403_29a70c2f70971db02df2a10ac064dca5.pdf |
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| collection | DOAJ |
| description | Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2-
arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3
yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl
(or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2-
pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l-methyl-5-
nitroimidazole-2-carboxaldehyde (7) with 6 in ethanol afforded compound 8 in good
yield. The antibacterial and antifungal activities of compounds 5,6 and 8 were
determined |
| format | Article |
| id | doaj-art-96c0dca6c53641abaa100d67177bf8d1 |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 1993-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-96c0dca6c53641abaa100d67177bf8d12025-08-20T01:53:31ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69141993-06-014231403SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVESReaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l-methyl-5- nitroimidazole-2-carboxaldehyde (7) with 6 in ethanol afforded compound 8 in good yield. The antibacterial and antifungal activities of compounds 5,6 and 8 were determinedhttps://jsciences.ut.ac.ir/article_31403_29a70c2f70971db02df2a10ac064dca5.pdf |
| spellingShingle | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES Journal of Sciences, Islamic Republic of Iran |
| title | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES |
| title_full | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES |
| title_fullStr | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES |
| title_full_unstemmed | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES |
| title_short | SYNTHESES, ANTIBACTERIAL AND
ANTIFUNGAL ACTIVITIES OF 2-ARYL-4-
QUINOLINE- CARBOXAMIDE DERIVATIVES |
| title_sort | syntheses antibacterial and antifungal activities of 2 aryl 4 quinoline carboxamide derivatives |
| url | https://jsciences.ut.ac.ir/article_31403_29a70c2f70971db02df2a10ac064dca5.pdf |