Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves*
Adequate colostrum intake is essential for neonatal calf health and development, not only reducing disease incidence but also promoting accelerated growth, earlier reproductive maturity, improved first-lactation milk yields, and lower culling rates. Although these advantages might be partly attribut...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | JDS Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666910225000237 |
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| author | L. Rostoll-Cangiano M. Cid de la Paz J.F. Pierre |
| author_facet | L. Rostoll-Cangiano M. Cid de la Paz J.F. Pierre |
| author_sort | L. Rostoll-Cangiano |
| collection | DOAJ |
| description | Adequate colostrum intake is essential for neonatal calf health and development, not only reducing disease incidence but also promoting accelerated growth, earlier reproductive maturity, improved first-lactation milk yields, and lower culling rates. Although these advantages might be partly attributed to antibody-mediated disease prevention, emerging evidence highlights the critical role of colostrum's bioactive components in programming postnatal development. Colostrum's nutrient and bioactive composition is uniquely tailored to meet the developmental needs of newborn calves. Compared with mature milk, colostrum contains higher concentrations of proteins, fats, vitamins, and minerals, along with an array of growth factors and bioactive molecules that exert a foundational influence on the adaptation to extrauterine life. A deeper understanding of how these colostrum bioactive components collectively influence calf health is important to improve colostrum management and pave the way for refined nutritional and care strategies to support calves during this critical developmental period. In this review, we explore the multifaceted role of bovine colostrum beyond transfer of passive immunity, focusing on its influence in modulating early microbial encounters and guiding neonatal immune development. |
| format | Article |
| id | doaj-art-96be8ce0d3f5468fb3a5b1a8e953ba6e |
| institution | OA Journals |
| issn | 2666-9102 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JDS Communications |
| spelling | doaj-art-96be8ce0d3f5468fb3a5b1a8e953ba6e2025-08-20T02:12:46ZengElsevierJDS Communications2666-91022025-05-016347447810.3168/jdsc.2024-0733Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves*L. Rostoll-Cangiano0M. Cid de la Paz1J.F. Pierre2Department of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706; Corresponding authorDepartment of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706Department of Nutritional Sciences, University of Wisconsin–Madison, Madison, WI 53706Adequate colostrum intake is essential for neonatal calf health and development, not only reducing disease incidence but also promoting accelerated growth, earlier reproductive maturity, improved first-lactation milk yields, and lower culling rates. Although these advantages might be partly attributed to antibody-mediated disease prevention, emerging evidence highlights the critical role of colostrum's bioactive components in programming postnatal development. Colostrum's nutrient and bioactive composition is uniquely tailored to meet the developmental needs of newborn calves. Compared with mature milk, colostrum contains higher concentrations of proteins, fats, vitamins, and minerals, along with an array of growth factors and bioactive molecules that exert a foundational influence on the adaptation to extrauterine life. A deeper understanding of how these colostrum bioactive components collectively influence calf health is important to improve colostrum management and pave the way for refined nutritional and care strategies to support calves during this critical developmental period. In this review, we explore the multifaceted role of bovine colostrum beyond transfer of passive immunity, focusing on its influence in modulating early microbial encounters and guiding neonatal immune development.http://www.sciencedirect.com/science/article/pii/S2666910225000237 |
| spellingShingle | L. Rostoll-Cangiano M. Cid de la Paz J.F. Pierre Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* JDS Communications |
| title | Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* |
| title_full | Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* |
| title_fullStr | Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* |
| title_full_unstemmed | Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* |
| title_short | Beyond immunoglobulin G: Dissecting the role of colostrum in programming early immune function in calves* |
| title_sort | beyond immunoglobulin g dissecting the role of colostrum in programming early immune function in calves |
| url | http://www.sciencedirect.com/science/article/pii/S2666910225000237 |
| work_keys_str_mv | AT lrostollcangiano beyondimmunoglobulingdissectingtheroleofcolostruminprogrammingearlyimmunefunctionincalves AT mciddelapaz beyondimmunoglobulingdissectingtheroleofcolostruminprogrammingearlyimmunefunctionincalves AT jfpierre beyondimmunoglobulingdissectingtheroleofcolostruminprogrammingearlyimmunefunctionincalves |