Duodenal coupling of pancreatic exocrine secretion and evacuatory activity of gastroduodenal complex
The aim of review. To present experimental and clinical data on enzyme-ergic regulatory coupling of exocrine pancreatic secretion and evacuatory activity of gastroduodenal complex.Original positions. Intraduodenal injection of pancreatin or trypsin as model of exocrine pancreatic secretion of enzyme...
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| Main Author: | |
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| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2011-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1405 |
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| Summary: | The aim of review. To present experimental and clinical data on enzyme-ergic regulatory coupling of exocrine pancreatic secretion and evacuatory activity of gastroduodenal complex.Original positions. Intraduodenal injection of pancreatin or trypsin as model of exocrine pancreatic secretion of enzymes accelerates gastric evacuation of chymus to the duodenum and decreases pancreatic secretion in dose-dependant w ay. Both effects result from inhibition of endogenous cholecystokinin release which is the main stimulant of pancreatic enzymes secretion and inhibitor of gastric evacuation, suppressing antral motility, reducing brake efficacy of duodenoantral reflux.Conclusion. Enzymatic, acid-base and nutrient properties of duodenal chymus link parameters of pancreatic exocrine secretion and gastroduodenal evacuatory activity. |
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| ISSN: | 1382-4376 2658-6673 |