The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation
The adult human heart has a limited ability to regenerate after injury, leading to the formation of fibrotic scars and a subsequent loss of function. In fish, mice, and humans, cardiac remodeling after myocardial injury involves the activation of epicardial and endocardial cells, pericytes, stem cel...
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MDPI AG
2025-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/12/875 |
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| author | Nicla Romano |
| author_facet | Nicla Romano |
| author_sort | Nicla Romano |
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| description | The adult human heart has a limited ability to regenerate after injury, leading to the formation of fibrotic scars and a subsequent loss of function. In fish, mice, and humans, cardiac remodeling after myocardial injury involves the activation of epicardial and endocardial cells, pericytes, stem cells, and fibroblasts. The heart’s extracellular matrix (ECM) plays a significant role in the regeneration and recovery process. The epicardium, endocardium, and pericytes reactivate the embryonic program in response to ECM stimulation, which leads to epithelial–mesenchymal transition, cell migration, and differentiation. This review analyzes the role of ECM in guiding the differentiation or dedifferentiation and proliferation of heart components by comparing significant findings in a zebrafish model with those of mammals. |
| format | Article |
| id | doaj-art-96bc843079604c128be48fd3bb574c4f |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-96bc843079604c128be48fd3bb574c4f2025-08-20T03:27:09ZengMDPI AGCells2073-44092025-06-01141287510.3390/cells14120875The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and DifferentiationNicla Romano0Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, ItalyThe adult human heart has a limited ability to regenerate after injury, leading to the formation of fibrotic scars and a subsequent loss of function. In fish, mice, and humans, cardiac remodeling after myocardial injury involves the activation of epicardial and endocardial cells, pericytes, stem cells, and fibroblasts. The heart’s extracellular matrix (ECM) plays a significant role in the regeneration and recovery process. The epicardium, endocardium, and pericytes reactivate the embryonic program in response to ECM stimulation, which leads to epithelial–mesenchymal transition, cell migration, and differentiation. This review analyzes the role of ECM in guiding the differentiation or dedifferentiation and proliferation of heart components by comparing significant findings in a zebrafish model with those of mammals.https://www.mdpi.com/2073-4409/14/12/875zebrafishheartextracellular matrix |
| spellingShingle | Nicla Romano The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation Cells zebrafish heart extracellular matrix |
| title | The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation |
| title_full | The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation |
| title_fullStr | The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation |
| title_full_unstemmed | The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation |
| title_short | The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation |
| title_sort | role of the extracellular matrix in inducing cardiac cell regeneration and differentiation |
| topic | zebrafish heart extracellular matrix |
| url | https://www.mdpi.com/2073-4409/14/12/875 |
| work_keys_str_mv | AT niclaromano theroleoftheextracellularmatrixininducingcardiaccellregenerationanddifferentiation AT niclaromano roleoftheextracellularmatrixininducingcardiaccellregenerationanddifferentiation |