Three-Dimensional Bioprinting for Intervertebral Disc Regeneration
The rising demand for organ transplants and the need for precise tissue models have positioned the in vitro biomanufacturing of tissues and organs as a pivotal area in regenerative treatment. Considerable development has been achieved in growing tissue-engineered intervertebral disc (IVD) scaffolds,...
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MDPI AG
2025-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/3/105 |
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| author | Md Amit Hasan Tanvir Md Abdul Khaleque Junhee Lee Jong-Beom Park Ga-Hyun Kim Hwan-Hee Lee Young-Yul Kim |
| author_facet | Md Amit Hasan Tanvir Md Abdul Khaleque Junhee Lee Jong-Beom Park Ga-Hyun Kim Hwan-Hee Lee Young-Yul Kim |
| author_sort | Md Amit Hasan Tanvir |
| collection | DOAJ |
| description | The rising demand for organ transplants and the need for precise tissue models have positioned the in vitro biomanufacturing of tissues and organs as a pivotal area in regenerative treatment. Considerable development has been achieved in growing tissue-engineered intervertebral disc (IVD) scaffolds, designed to meet stringent mechanical and biological compatibility criteria. Among the cutting-edge approaches, 3D bioprinting stands out due to its unparalleled capacity to organize biomaterials, bioactive molecules, and living cells with high precision. Despite these advancements, polymer-based scaffolds still encounter limitations in replicating the extracellular matrix (ECM)-like environment, which is fundamental for optimal cellular activities. To overcome these challenges, integrating polymers with hydrogels has been recommended as a promising solution. This combination enables the advancement of porous scaffolds that nurture cell adhesion, proliferation, as well as differentiation. Additionally, bioinks derived from the decellularized extracellular matrix (dECM) have exhibited potential in replicating biologically relevant microenvironments, enhancing cell viability, differentiation, and motility. Hydrogels, whether derived from natural sources involving collagen and alginate or synthesized chemically, are highly valued for their ECM-like properties and superior biocompatibility. This review will explore recent advancements in techniques and technologies for IVD regeneration. Emphasis will be placed on identifying research gaps and proposing strategies to bridge them, with the goal of accelerating the translation of IVDs into clinical applications. |
| format | Article |
| id | doaj-art-96bb69373720410380a67e5cb2cd2a65 |
| institution | OA Journals |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Journal of Functional Biomaterials |
| spelling | doaj-art-96bb69373720410380a67e5cb2cd2a652025-08-20T01:48:56ZengMDPI AGJournal of Functional Biomaterials2079-49832025-03-0116310510.3390/jfb16030105Three-Dimensional Bioprinting for Intervertebral Disc RegenerationMd Amit Hasan Tanvir0Md Abdul Khaleque1Junhee Lee2Jong-Beom Park3Ga-Hyun Kim4Hwan-Hee Lee5Young-Yul Kim6Department of Orthopedic Surgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Seoul 34943, Republic of KoreaDepartment of Orthopedic Surgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Seoul 34943, Republic of KoreaDepartment of Bionic Machinery, KIMM Institute of AI Robot, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of KoreaDepartment of Orthopedic Surgery, Uijeongbu Saint Mary’s Hospital, The Catholic University of Korea, Seoul 11765, Republic of KoreaDepartment of Orthopedic Surgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Seoul 34943, Republic of KoreaDepartment of Orthopedic Surgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Seoul 34943, Republic of KoreaDepartment of Orthopedic Surgery, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Seoul 34943, Republic of KoreaThe rising demand for organ transplants and the need for precise tissue models have positioned the in vitro biomanufacturing of tissues and organs as a pivotal area in regenerative treatment. Considerable development has been achieved in growing tissue-engineered intervertebral disc (IVD) scaffolds, designed to meet stringent mechanical and biological compatibility criteria. Among the cutting-edge approaches, 3D bioprinting stands out due to its unparalleled capacity to organize biomaterials, bioactive molecules, and living cells with high precision. Despite these advancements, polymer-based scaffolds still encounter limitations in replicating the extracellular matrix (ECM)-like environment, which is fundamental for optimal cellular activities. To overcome these challenges, integrating polymers with hydrogels has been recommended as a promising solution. This combination enables the advancement of porous scaffolds that nurture cell adhesion, proliferation, as well as differentiation. Additionally, bioinks derived from the decellularized extracellular matrix (dECM) have exhibited potential in replicating biologically relevant microenvironments, enhancing cell viability, differentiation, and motility. Hydrogels, whether derived from natural sources involving collagen and alginate or synthesized chemically, are highly valued for their ECM-like properties and superior biocompatibility. This review will explore recent advancements in techniques and technologies for IVD regeneration. Emphasis will be placed on identifying research gaps and proposing strategies to bridge them, with the goal of accelerating the translation of IVDs into clinical applications.https://www.mdpi.com/2079-4983/16/3/1053D bioprintingbiomaterialsdECMIVD |
| spellingShingle | Md Amit Hasan Tanvir Md Abdul Khaleque Junhee Lee Jong-Beom Park Ga-Hyun Kim Hwan-Hee Lee Young-Yul Kim Three-Dimensional Bioprinting for Intervertebral Disc Regeneration Journal of Functional Biomaterials 3D bioprinting biomaterials dECM IVD |
| title | Three-Dimensional Bioprinting for Intervertebral Disc Regeneration |
| title_full | Three-Dimensional Bioprinting for Intervertebral Disc Regeneration |
| title_fullStr | Three-Dimensional Bioprinting for Intervertebral Disc Regeneration |
| title_full_unstemmed | Three-Dimensional Bioprinting for Intervertebral Disc Regeneration |
| title_short | Three-Dimensional Bioprinting for Intervertebral Disc Regeneration |
| title_sort | three dimensional bioprinting for intervertebral disc regeneration |
| topic | 3D bioprinting biomaterials dECM IVD |
| url | https://www.mdpi.com/2079-4983/16/3/105 |
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