Cholestasis in Crohn's Disease: A Diagnostic Challenge
A 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. The first episode was related to...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1997/203843 |
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| _version_ | 1832563582400724992 |
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| author | Nir Hilzenrat Esther Lamoureux Averell Sherker Albert Cohen |
| author_facet | Nir Hilzenrat Esther Lamoureux Averell Sherker Albert Cohen |
| author_sort | Nir Hilzenrat |
| collection | DOAJ |
| description | A 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. The first episode was related to an idiosyncratic drug reaction while on sulfasalazine. The second episode, at the time of an exacerbation of his colitis, was characterized by moderate portal inflammation on liver biopsy and resolved quickly while he was on corticosteroid therapy. The most recent episode, occurring when the bowel disease was quiescent, was due to granulomatous hepatitis and resolved clinically with no specific therapy. Because numerous potentially serious hepatobiliary complications have been associated with inflammatory bowel disease, prompt and aggressive investigation in these instances is recommended. |
| format | Article |
| id | doaj-art-96b9bbc018e24b00b06d422604bfe8ca |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-96b9bbc018e24b00b06d422604bfe8ca2025-02-03T01:13:10ZengWileyCanadian Journal of Gastroenterology0835-79001997-01-01111353710.1155/1997/203843Cholestasis in Crohn's Disease: A Diagnostic ChallengeNir HilzenratEsther LamoureuxAverell SherkerAlbert CohenA 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. The first episode was related to an idiosyncratic drug reaction while on sulfasalazine. The second episode, at the time of an exacerbation of his colitis, was characterized by moderate portal inflammation on liver biopsy and resolved quickly while he was on corticosteroid therapy. The most recent episode, occurring when the bowel disease was quiescent, was due to granulomatous hepatitis and resolved clinically with no specific therapy. Because numerous potentially serious hepatobiliary complications have been associated with inflammatory bowel disease, prompt and aggressive investigation in these instances is recommended.http://dx.doi.org/10.1155/1997/203843 |
| spellingShingle | Nir Hilzenrat Esther Lamoureux Averell Sherker Albert Cohen Cholestasis in Crohn's Disease: A Diagnostic Challenge Canadian Journal of Gastroenterology |
| title | Cholestasis in Crohn's Disease: A Diagnostic Challenge |
| title_full | Cholestasis in Crohn's Disease: A Diagnostic Challenge |
| title_fullStr | Cholestasis in Crohn's Disease: A Diagnostic Challenge |
| title_full_unstemmed | Cholestasis in Crohn's Disease: A Diagnostic Challenge |
| title_short | Cholestasis in Crohn's Disease: A Diagnostic Challenge |
| title_sort | cholestasis in crohn s disease a diagnostic challenge |
| url | http://dx.doi.org/10.1155/1997/203843 |
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