HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia
A simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic of levofloxacin in 18 healthy volunteers afte...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2013-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/126 |
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| author | S. N. Kondratenko A. K. Starodubtcev E. A. Senik O. V. Dralova S. N. Kudinova |
| author_facet | S. N. Kondratenko A. K. Starodubtcev E. A. Senik O. V. Dralova S. N. Kudinova |
| author_sort | S. N. Kondratenko |
| collection | DOAJ |
| description | A simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic of levofloxacin in 18 healthy volunteers after a single oral dose of 500 mg. Found that the drug being tested, levofloxacin (OOO «Ozone», Russia) is bioequivalent to the reference drugs Tavanic® («Sanofi Winthrop Industry», France). |
| format | Article |
| id | doaj-art-96b39403178d496ca5db682e2795feca |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2013-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-96b39403178d496ca5db682e2795feca2025-08-20T03:20:16ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302013-04-01012326125HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», RussiaS. N. Kondratenko0A. K. Starodubtcev1E. A. Senik2O. V. Dralova3S. N. Kudinova4First Moscow State Medical University I.M. SechenovFirst Moscow State Medical University I.M. SechenovFirst Moscow State Medical University I.M. SechenovFirst Moscow State Medical University I.M. SechenovFirst Moscow State Medical University I.M. SechenovA simple, specific, sensitive and reproducible good method for quantitative determination of Levofloxacin in plasma using HPLC with UV-spectrophotometric detection. With this technique the pharmacokinetics and relative bioavailability of domestic generic of levofloxacin in 18 healthy volunteers after a single oral dose of 500 mg. Found that the drug being tested, levofloxacin (OOO «Ozone», Russia) is bioequivalent to the reference drugs Tavanic® («Sanofi Winthrop Industry», France).https://www.pharmacokinetica.ru/jour/article/view/126левофлоксацинвэжхплазма кровифармакокинетикабиодоступностьбиоэквивалентностьвоспроизведённые препаратыдженерикlevofloxacinhplcblood plasmapharmacokineticsbioavailabilitybioequivalencegeneric drugsgeneric |
| spellingShingle | S. N. Kondratenko A. K. Starodubtcev E. A. Senik O. V. Dralova S. N. Kudinova HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia Фармакокинетика и Фармакодинамика левофлоксацин вэжх плазма крови фармакокинетика биодоступность биоэквивалентность воспроизведённые препараты дженерик levofloxacin hplc blood plasma pharmacokinetics bioavailability bioequivalence generic drugs generic |
| title | HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia |
| title_full | HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia |
| title_fullStr | HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia |
| title_full_unstemmed | HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia |
| title_short | HPLC determination, pharmacokinetics and relative bioavailability of levofloxacin produced by «OZONE», Russia |
| title_sort | hplc determination pharmacokinetics and relative bioavailability of levofloxacin produced by ozone russia |
| topic | левофлоксацин вэжх плазма крови фармакокинетика биодоступность биоэквивалентность воспроизведённые препараты дженерик levofloxacin hplc blood plasma pharmacokinetics bioavailability bioequivalence generic drugs generic |
| url | https://www.pharmacokinetica.ru/jour/article/view/126 |
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