Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease
Abstract This study aimed to evaluate the impact of Fabry disease (FD) on retinal microvasculature using optical coherence tomography angiography (OCTA), arterial stiffness, and the resistive index (RI) of the central retinal artery (CRA) in early disease stages. Twenty-nine genetically confirmed FD...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-74146-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181418170187776 |
|---|---|
| author | Michele Rinaldi Flavia Chiosi Maria Laura Passaro Francesco Natale Alessia Riccardo Luca D’Andrea Martina Caiazza Marta Rubino Emanuele Monda Gilda Cennamo Francesco Calabrò Giuseppe Limongelli Ciro Costagliola |
| author_facet | Michele Rinaldi Flavia Chiosi Maria Laura Passaro Francesco Natale Alessia Riccardo Luca D’Andrea Martina Caiazza Marta Rubino Emanuele Monda Gilda Cennamo Francesco Calabrò Giuseppe Limongelli Ciro Costagliola |
| author_sort | Michele Rinaldi |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the impact of Fabry disease (FD) on retinal microvasculature using optical coherence tomography angiography (OCTA), arterial stiffness, and the resistive index (RI) of the central retinal artery (CRA) in early disease stages. Twenty-nine genetically confirmed FD patients and twenty-six healthy controls were enrolled. Vessel density (VD) values of the superficial, deep, and choriocapillaris plexuses (SCP, DCP, and CC) were measured via OCTA. CRA RI was studied using color Doppler and grayscale sonography, and aortic pulse wave velocity (PWV) was assessed with the Complior method. CRA RI was significantly lower in the control group compared to the Fabry group (p < 0.001). Central VD was found to be significantly higher in the control group compared to the Fabry group in all the retinal layers (SCP (p < 0.001), DCP (p < 0.005), CC (p < 0.001)). PWV was significantly higher in the Fabry group than in the control group (p = 0.03). Fabry disease patients demonstrate elevated arterial stiffness, increased CRA RI, and diminished retinal microvascular density compared to healthy controls, indicating early ocular damage. Continuous monitoring and targeted screening for organ impairment are crucial in FD management. Identifying biomarkers for assessing ocular vascular involvement and treatment response is imperative. Further research is needed. |
| format | Article |
| id | doaj-art-96b0aaf653bd4ae78f1232f689b26f53 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-96b0aaf653bd4ae78f1232f689b26f532025-08-20T02:17:54ZengNature PortfolioScientific Reports2045-23222024-10-0114111010.1038/s41598-024-74146-5Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry diseaseMichele Rinaldi0Flavia Chiosi1Maria Laura Passaro2Francesco Natale3Alessia Riccardo4Luca D’Andrea5Martina Caiazza6Marta Rubino7Emanuele Monda8Gilda Cennamo9Francesco Calabrò10Giuseppe Limongelli11Ciro Costagliola12Department of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesDepartment of Ophthalmology, Azienda Ospedaliera dei Colli, Monaldi HospitalDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesDepartment of Cardiothoracic Sciences, University of Campania “Luigi Vanvitelli”, Monaldi HospitalDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi HospitalInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi HospitalInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi HospitalDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesDepartment of Ophthalmology, Azienda Ospedaliera dei Colli, Monaldi HospitalInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi HospitalDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of NaplesAbstract This study aimed to evaluate the impact of Fabry disease (FD) on retinal microvasculature using optical coherence tomography angiography (OCTA), arterial stiffness, and the resistive index (RI) of the central retinal artery (CRA) in early disease stages. Twenty-nine genetically confirmed FD patients and twenty-six healthy controls were enrolled. Vessel density (VD) values of the superficial, deep, and choriocapillaris plexuses (SCP, DCP, and CC) were measured via OCTA. CRA RI was studied using color Doppler and grayscale sonography, and aortic pulse wave velocity (PWV) was assessed with the Complior method. CRA RI was significantly lower in the control group compared to the Fabry group (p < 0.001). Central VD was found to be significantly higher in the control group compared to the Fabry group in all the retinal layers (SCP (p < 0.001), DCP (p < 0.005), CC (p < 0.001)). PWV was significantly higher in the Fabry group than in the control group (p = 0.03). Fabry disease patients demonstrate elevated arterial stiffness, increased CRA RI, and diminished retinal microvascular density compared to healthy controls, indicating early ocular damage. Continuous monitoring and targeted screening for organ impairment are crucial in FD management. Identifying biomarkers for assessing ocular vascular involvement and treatment response is imperative. Further research is needed.https://doi.org/10.1038/s41598-024-74146-5Fabry diseaseRetinal vessel densityRetinal and choroidal microangiopathyOCT angiographyResistive index of central retinal artery |
| spellingShingle | Michele Rinaldi Flavia Chiosi Maria Laura Passaro Francesco Natale Alessia Riccardo Luca D’Andrea Martina Caiazza Marta Rubino Emanuele Monda Gilda Cennamo Francesco Calabrò Giuseppe Limongelli Ciro Costagliola Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease Scientific Reports Fabry disease Retinal vessel density Retinal and choroidal microangiopathy OCT angiography Resistive index of central retinal artery |
| title | Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease |
| title_full | Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease |
| title_fullStr | Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease |
| title_full_unstemmed | Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease |
| title_short | Resistive index of central retinal artery, aortic arterial stiffness and OCTA correlated parameters in the early stage of fabry disease |
| title_sort | resistive index of central retinal artery aortic arterial stiffness and octa correlated parameters in the early stage of fabry disease |
| topic | Fabry disease Retinal vessel density Retinal and choroidal microangiopathy OCT angiography Resistive index of central retinal artery |
| url | https://doi.org/10.1038/s41598-024-74146-5 |
| work_keys_str_mv | AT michelerinaldi resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT flaviachiosi resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT marialaurapassaro resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT francesconatale resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT alessiariccardo resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT lucadandrea resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT martinacaiazza resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT martarubino resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT emanuelemonda resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT gildacennamo resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT francescocalabro resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT giuseppelimongelli resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease AT cirocostagliola resistiveindexofcentralretinalarteryaorticarterialstiffnessandoctacorrelatedparametersintheearlystageoffabrydisease |