CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
We studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2016-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/1042 |
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| _version_ | 1849401512676032512 |
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| author | E. G. Lobanova E. P. Kalinina Yu. K. Denisenko |
| author_facet | E. G. Lobanova E. P. Kalinina Yu. K. Denisenko |
| author_sort | E. G. Lobanova |
| collection | DOAJ |
| description | We studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,IL-17A, IL-21, IFNγ, TGF-β1. We found that the shift in balance of pro- and anti-inflammatory cytokines is typical to both Th1 and Th17 immune response types in COPD of different severity. The variety of immune response types was achieved due to activation of different effector cells. I.e., the Th1 response was associated with macrophage activation and IFNγ induction, whereas domination of Th17 response was accompanied by activation of neutrophils, and increased synthesis of IL-17, IL-21. The Th17 type of immune response was shown to prevail in severe COPD. Thus, the certain types of immune disorders in COPD presume application of combined therapy including immunocorrective drugs which are able to suppress inflammation and correct the cytokine imbalances. |
| format | Article |
| id | doaj-art-96ad2cdfeab54106a5ff87be5e56ca56 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2016-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-96ad2cdfeab54106a5ff87be5e56ca562025-08-20T03:37:45ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2016-07-0118328729010.15789/1563-0625-2016-3-287-290843CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASEE. G. Lobanova0E. P. Kalinina1Yu. K. Denisenko2Far Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian FederationFar Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian FederationFar Eastern Research Centre of Respiratory Physiology and Pathology – Institute of Medical Climatology and Rehabilitation, Vladivostok Branch, Vladivostok, Russian FederationWe studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,IL-17A, IL-21, IFNγ, TGF-β1. We found that the shift in balance of pro- and anti-inflammatory cytokines is typical to both Th1 and Th17 immune response types in COPD of different severity. The variety of immune response types was achieved due to activation of different effector cells. I.e., the Th1 response was associated with macrophage activation and IFNγ induction, whereas domination of Th17 response was accompanied by activation of neutrophils, and increased synthesis of IL-17, IL-21. The Th17 type of immune response was shown to prevail in severe COPD. Thus, the certain types of immune disorders in COPD presume application of combined therapy including immunocorrective drugs which are able to suppress inflammation and correct the cytokine imbalances.https://www.mimmun.ru/mimmun/article/view/1042chronic obstructive pulmonary diseaset helpersth1th17 typecytokinesimmunе regulation |
| spellingShingle | E. G. Lobanova E. P. Kalinina Yu. K. Denisenko CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Медицинская иммунология chronic obstructive pulmonary disease t helpers th1 th17 type cytokines immunе regulation |
| title | CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full | CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr | CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed | CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short | CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort | cytokine contents in th1 and th17 type lymphocytes in chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease t helpers th1 th17 type cytokines immunе regulation |
| url | https://www.mimmun.ru/mimmun/article/view/1042 |
| work_keys_str_mv | AT eglobanova cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease AT epkalinina cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease AT yukdenisenko cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease |