Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations
<i>Bifidobacterium adolescentis</i> is prevalent in the gastrointestinal tract of healthy humans, and significantly influences host health. Recent studies have predominantly investigated the probiotic characteristics of individual strains and their specific metabolic roles, whereas analy...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-08-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/14/15/2747 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849239523689496576 |
|---|---|
| author | Pei Fu Hao Qi Wenjun Liu |
| author_facet | Pei Fu Hao Qi Wenjun Liu |
| author_sort | Pei Fu |
| collection | DOAJ |
| description | <i>Bifidobacterium adolescentis</i> is prevalent in the gastrointestinal tract of healthy humans, and significantly influences host health. Recent studies have predominantly investigated the probiotic characteristics of individual strains and their specific metabolic roles, whereas analyses at the population genome level have been limited to date. This study conducted a comparative genomics analysis of 543 <i>B. adolescentis</i> genomes to explore genetic background variations and functional gene differences across geographically diverse populations. The results revealed significant differences in genome size and GC content among populations from Asia, Europe, and North America (<i>p</i> < 0.05). The pan-gene exhibited an open structure, reflecting the substantial genetic diversity within <i>B. adolescentis</i>. Functional annotation demonstrated that <i>B. adolescentis</i> possesses numerous protein-coding genes and abundant carbohydrate-active enzymes (CAZys) implicated in carbohydrate degradation and transformation. Population-specific CAZys were identified, suggesting adaptive evolution driven by distinct regional dietary patterns. |
| format | Article |
| id | doaj-art-96abd29cb8df449ca1f87ec061c3c4b5 |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-96abd29cb8df449ca1f87ec061c3c4b52025-08-20T04:00:55ZengMDPI AGFoods2304-81582025-08-011415274710.3390/foods14152747Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut PopulationsPei Fu0Hao Qi1Wenjun Liu2Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China<i>Bifidobacterium adolescentis</i> is prevalent in the gastrointestinal tract of healthy humans, and significantly influences host health. Recent studies have predominantly investigated the probiotic characteristics of individual strains and their specific metabolic roles, whereas analyses at the population genome level have been limited to date. This study conducted a comparative genomics analysis of 543 <i>B. adolescentis</i> genomes to explore genetic background variations and functional gene differences across geographically diverse populations. The results revealed significant differences in genome size and GC content among populations from Asia, Europe, and North America (<i>p</i> < 0.05). The pan-gene exhibited an open structure, reflecting the substantial genetic diversity within <i>B. adolescentis</i>. Functional annotation demonstrated that <i>B. adolescentis</i> possesses numerous protein-coding genes and abundant carbohydrate-active enzymes (CAZys) implicated in carbohydrate degradation and transformation. Population-specific CAZys were identified, suggesting adaptive evolution driven by distinct regional dietary patterns.https://www.mdpi.com/2304-8158/14/15/2747<i>Bifidobacterium adolescentis</i>comparative genomicsfunctional gene annotationadaptive evolution |
| spellingShingle | Pei Fu Hao Qi Wenjun Liu Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations Foods <i>Bifidobacterium adolescentis</i> comparative genomics functional gene annotation adaptive evolution |
| title | Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations |
| title_full | Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations |
| title_fullStr | Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations |
| title_full_unstemmed | Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations |
| title_short | Comparative Genomics and Adaptive Evolution of <i>Bifidobacterium adolescentis</i> in Geographically Distinct Human Gut Populations |
| title_sort | comparative genomics and adaptive evolution of i bifidobacterium adolescentis i in geographically distinct human gut populations |
| topic | <i>Bifidobacterium adolescentis</i> comparative genomics functional gene annotation adaptive evolution |
| url | https://www.mdpi.com/2304-8158/14/15/2747 |
| work_keys_str_mv | AT peifu comparativegenomicsandadaptiveevolutionofibifidobacteriumadolescentisiingeographicallydistincthumangutpopulations AT haoqi comparativegenomicsandadaptiveevolutionofibifidobacteriumadolescentisiingeographicallydistincthumangutpopulations AT wenjunliu comparativegenomicsandadaptiveevolutionofibifidobacteriumadolescentisiingeographicallydistincthumangutpopulations |